Fumagillin Attenuates Spinal Angiogenesis, Neuroinflammation, and Pain in Neuropathic Rats after Chronic Constriction Injury

Fumagillin Attenuates Spinal Angiogenesis, Neuroinflammation, and Pain in Neuropathic Rats after Chronic Constriction Injury

Introduction: Angiogenesis in the central nervous system is visible in animal models of neuroinflammation and bone cancer pain. However, whether spinal angiogenesis exists and contributes to central sensitization in neuropathic pain remains unclear. This study analyzes the impact of angiogenesis on...

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Bibliographic Details
Main Authors: Zhi-Hong Wen, Shi-Ying Huang, Hsiao-Mei Kuo, Chao-Ting Chen, Nan-Fu Chen, Wu-Fu Chen, Kuan-Hao Tsui, Hsin-Tzu Liu, Chun-Sung Sung
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Biomedicines
Subjects:
angiogenesis
astrocytes
fumagillin
neuroinflammation
neuropathic pain
Online Access:https://www.mdpi.com/2227-9059/9/9/1187

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