The analysis of matrix metalloproteinase-8 in gingival crevicular fluid and periodontal diseases

Background: Periodontal disease, also generally called periodontitis or gum disease, is a chronic infection-induced inflammatory disease that causes tooth loss if not properly treated, and is considered as a modifying factor in systemic health. Gingival crevicular fluid (GCF) matrix metalloproteinas...

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Main Authors: Nila Kasuma, Fadil Oenzil, Eryati Darwin, Yanwirasti Sofyan
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Indian Journal of Dental Research
Subjects:
Online Access:http://www.ijdr.in/article.asp?issn=0970-9290;year=2018;volume=29;issue=4;spage=450;epage=454;aulast=Kasuma
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spelling doaj-f31fdd15b43e49b8b41a3b74b8bde10f2020-11-25T02:44:55ZengWolters Kluwer Medknow PublicationsIndian Journal of Dental Research0970-92901998-36032018-01-0129445045410.4103/ijdr.IJDR_97_15The analysis of matrix metalloproteinase-8 in gingival crevicular fluid and periodontal diseasesNila KasumaFadil OenzilEryati DarwinYanwirasti SofyanBackground: Periodontal disease, also generally called periodontitis or gum disease, is a chronic infection-induced inflammatory disease that causes tooth loss if not properly treated, and is considered as a modifying factor in systemic health. Gingival crevicular fluid (GCF) matrix metalloproteinase-8 (MMP-8) is an inflammatory marker found in periodontal pathologic conditions. Gingivitis, a nondestructive type of periodontal disease, can progress to periodontitis if left untreated. Therefore, assessing the level of MMP-8 with comfortable methods and no tissue intervention can determine the progression of the periodontal disease for a better treatment. Objective: The purpose of the present study is to determine the relationship between MMP-8 in GCF and periodontal disease. Setting and Design: This is a cross-sectional study that took place in West Sumatra, Indonesia from June to December 2013. Materials and Methods: This study involves 60 respondents who are divided into three groups based on the periodontal disease index. The samples consist of 20 healthy individuals, 20 with mild gingivitis, and 20 periodontitis initial. GCF was collected from each group. MMP8 level in GCF was tested by using ELISA technique. Statistical Analysis: Data were analyzed with SPSS version 17 Software. ANOVA test was used to determine the differences in average levels of MMP-8. Bonferroni post hoc test was used to discover which spesific means differed. Results: The level of MMP-8 is significantly different between the healthy group and mild gingivitis group, between the healthy group with mild periodontitis group, and also between groups with mild gingivitis and mild periodontitis (P < 0.05). Conclusion: The findings of this study can be used by practitioners of dentistry to establish a proper diagnosis and appropriate treatment of periodontal disease by measuring the scale of MMP-8, to prevent or to minimize further complication in periodontitis patients.http://www.ijdr.in/article.asp?issn=0970-9290;year=2018;volume=29;issue=4;spage=450;epage=454;aulast=KasumaMatrix metalloproteinase-8periodontal diseasegingival crevicular fluid
collection DOAJ
language English
format Article
sources DOAJ
author Nila Kasuma
Fadil Oenzil
Eryati Darwin
Yanwirasti Sofyan
spellingShingle Nila Kasuma
Fadil Oenzil
Eryati Darwin
Yanwirasti Sofyan
The analysis of matrix metalloproteinase-8 in gingival crevicular fluid and periodontal diseases
Indian Journal of Dental Research
Matrix metalloproteinase-8
periodontal disease
gingival crevicular fluid
author_facet Nila Kasuma
Fadil Oenzil
Eryati Darwin
Yanwirasti Sofyan
author_sort Nila Kasuma
title The analysis of matrix metalloproteinase-8 in gingival crevicular fluid and periodontal diseases
title_short The analysis of matrix metalloproteinase-8 in gingival crevicular fluid and periodontal diseases
title_full The analysis of matrix metalloproteinase-8 in gingival crevicular fluid and periodontal diseases
title_fullStr The analysis of matrix metalloproteinase-8 in gingival crevicular fluid and periodontal diseases
title_full_unstemmed The analysis of matrix metalloproteinase-8 in gingival crevicular fluid and periodontal diseases
title_sort analysis of matrix metalloproteinase-8 in gingival crevicular fluid and periodontal diseases
publisher Wolters Kluwer Medknow Publications
series Indian Journal of Dental Research
issn 0970-9290
1998-3603
publishDate 2018-01-01
description Background: Periodontal disease, also generally called periodontitis or gum disease, is a chronic infection-induced inflammatory disease that causes tooth loss if not properly treated, and is considered as a modifying factor in systemic health. Gingival crevicular fluid (GCF) matrix metalloproteinase-8 (MMP-8) is an inflammatory marker found in periodontal pathologic conditions. Gingivitis, a nondestructive type of periodontal disease, can progress to periodontitis if left untreated. Therefore, assessing the level of MMP-8 with comfortable methods and no tissue intervention can determine the progression of the periodontal disease for a better treatment. Objective: The purpose of the present study is to determine the relationship between MMP-8 in GCF and periodontal disease. Setting and Design: This is a cross-sectional study that took place in West Sumatra, Indonesia from June to December 2013. Materials and Methods: This study involves 60 respondents who are divided into three groups based on the periodontal disease index. The samples consist of 20 healthy individuals, 20 with mild gingivitis, and 20 periodontitis initial. GCF was collected from each group. MMP8 level in GCF was tested by using ELISA technique. Statistical Analysis: Data were analyzed with SPSS version 17 Software. ANOVA test was used to determine the differences in average levels of MMP-8. Bonferroni post hoc test was used to discover which spesific means differed. Results: The level of MMP-8 is significantly different between the healthy group and mild gingivitis group, between the healthy group with mild periodontitis group, and also between groups with mild gingivitis and mild periodontitis (P < 0.05). Conclusion: The findings of this study can be used by practitioners of dentistry to establish a proper diagnosis and appropriate treatment of periodontal disease by measuring the scale of MMP-8, to prevent or to minimize further complication in periodontitis patients.
topic Matrix metalloproteinase-8
periodontal disease
gingival crevicular fluid
url http://www.ijdr.in/article.asp?issn=0970-9290;year=2018;volume=29;issue=4;spage=450;epage=454;aulast=Kasuma
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