Effects of Valsartan vs Amlodipin on renal function in salt loaded spontaneously hypertensive rats
The goal of this study was to compare the effects of valsartan and amlodipin on the systolic blood pressure and parameters specific to the renal function in salt loaded spontaneously hypertensive rats (SHR). 32 male SHR were used at age of 20 weeks and body weight ranging between 265-300 g. From 8...
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University Ss Cyril and Methodius in Skopje, Faculty of Pharmacy and Macedonian Pharmaceutical Association
2014-06-01
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Series: | Makedonsko Farmacevtski Bilten |
Online Access: | http://bulletin.mfd.org.mk/volumes/Volume%2060/60_007.pdf |
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doaj-f329e28cc55d476593b0a59f9681255f2020-11-24T23:09:19ZengUniversity Ss Cyril and Methodius in Skopje, Faculty of Pharmacy and Macedonian Pharmaceutical AssociationMakedonsko Farmacevtski Bilten1409-86951857-89692014-06-0160(1)5359Effects of Valsartan vs Amlodipin on renal function in salt loaded spontaneously hypertensive rats Kalina Gjorgjievska0Dimce Zafirov1Maja Jurhar Pavlova2Svetlana Cekovska3Institute of Preclinical and Clinical Pharmacology with Toxicology, Medical Faculty, SkopjeInstitute of Preclinical and Clinical Pharmacology with Toxicology, Medical Faculty, SkopjeInstitute of Microbiology and Parasitology, Medical Faculty, SkopjeInstitute of Medical and Experimental Biochemistry, Medical Faculty, SkopjeThe goal of this study was to compare the effects of valsartan and amlodipin on the systolic blood pressure and parameters specific to the renal function in salt loaded spontaneously hypertensive rats (SHR). 32 male SHR were used at age of 20 weeks and body weight ranging between 265-300 g. From 8 weeks of age tab water was replaced with a solution of NaCl (1%) given ad libitum. Rats were divided into 2 groups: valsartan treated group SHRVAL (n=16) in which valsartan was given at a dose of 10 mg/kg b. w. and amlodipine treated group SHRAMLO (n=16) in which amlodipine was given at a dose of 5 mg/kg b. w. For a period of 12 weeks we have evaluated the effect of the investigated drugs on systolic blood pressure, body weight and renal function tests. In salt loaded rats amlodipine was more effective in reducing the systolic blood pressure in contrast to valsartan who had more pronounced effect on renal parameters most evident in proteinuria. Since both treatment groups have different mechanism of action a combination therapy may be beneficial in improving renal function in SHR rats.http://bulletin.mfd.org.mk/volumes/Volume%2060/60_007.pdf |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kalina Gjorgjievska Dimce Zafirov Maja Jurhar Pavlova Svetlana Cekovska |
spellingShingle |
Kalina Gjorgjievska Dimce Zafirov Maja Jurhar Pavlova Svetlana Cekovska Effects of Valsartan vs Amlodipin on renal function in salt loaded spontaneously hypertensive rats Makedonsko Farmacevtski Bilten |
author_facet |
Kalina Gjorgjievska Dimce Zafirov Maja Jurhar Pavlova Svetlana Cekovska |
author_sort |
Kalina Gjorgjievska |
title |
Effects of Valsartan vs Amlodipin on renal function in salt loaded spontaneously hypertensive rats |
title_short |
Effects of Valsartan vs Amlodipin on renal function in salt loaded spontaneously hypertensive rats |
title_full |
Effects of Valsartan vs Amlodipin on renal function in salt loaded spontaneously hypertensive rats |
title_fullStr |
Effects of Valsartan vs Amlodipin on renal function in salt loaded spontaneously hypertensive rats |
title_full_unstemmed |
Effects of Valsartan vs Amlodipin on renal function in salt loaded spontaneously hypertensive rats |
title_sort |
effects of valsartan vs amlodipin on renal function in salt loaded spontaneously hypertensive rats |
publisher |
University Ss Cyril and Methodius in Skopje, Faculty of Pharmacy and Macedonian Pharmaceutical Association |
series |
Makedonsko Farmacevtski Bilten |
issn |
1409-8695 1857-8969 |
publishDate |
2014-06-01 |
description |
The goal of this study was to compare the effects of valsartan and amlodipin on the systolic blood pressure and parameters specific
to the renal function in salt loaded spontaneously hypertensive rats (SHR). 32 male SHR were used at age of 20 weeks and body weight ranging between 265-300 g. From 8 weeks of age tab water was replaced with a solution of NaCl (1%) given ad libitum. Rats were divided into 2 groups: valsartan treated group SHRVAL (n=16) in which valsartan was given at a dose of 10 mg/kg b. w. and amlodipine treated group SHRAMLO (n=16) in which amlodipine was given at a dose of 5 mg/kg b. w. For a period of 12 weeks we have evaluated the effect of the investigated drugs on systolic blood pressure, body weight and renal function tests. In salt loaded rats amlodipine was more effective in reducing the systolic blood pressure in contrast to valsartan who had more pronounced effect on renal parameters most evident in proteinuria. Since both treatment groups have different mechanism of action a combination therapy may be beneficial in improving renal
function in SHR rats. |
url |
http://bulletin.mfd.org.mk/volumes/Volume%2060/60_007.pdf |
work_keys_str_mv |
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