A translational continuum of model systems for evaluating treatment strategies in Alzheimer’s disease: isradipine as a candidate drug
SUMMARY A growing body of evidence supports the ‘calcium hypothesis’ of Alzheimer’s disease (AD), which postulates that a variety of insults might disrupt the homeostatic regulation of neuronal calcium (Ca2+) in the brain, resulting in the progressive symptoms that typify the disease. However, despi...
Main Authors: | Philip F. Copenhaver, Thimmappa S. Anekonda, Derek Musashe, Kristine M. Robinson, Jenna M. Ramaker, Tracy L. Swanson, Teri L. Wadsworth, Doris Kretzschmar, Randall L. Woltjer, Joseph F. Quinn |
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Format: | Article |
Language: | English |
Published: |
The Company of Biologists
2011-09-01
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Series: | Disease Models & Mechanisms |
Online Access: | http://dmm.biologists.org/content/4/5/634 |
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