Antibodies to Cardiolipin in Patients with Primary Biliary Cirrhosis

Antibodies to cardiolipin have been recognized in up to 65% of patients with systemic lupus erythematosus. It has been claimed that they are significantly associated with intravascular thrombosis and with obstetrical complications. Thus far they have been found to be less prevalent in other diseases...

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Main Authors: John Verrier Jones, Dianne P. Mosher, Edith Jones, C. Noel Williams, Dickran Malatjalian, Roland I. Carr, Mervat Mansour
Format: Article
Language:English
Published: Hindawi Limited 1989-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/1989/806380
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spelling doaj-f35717e7fc8a4af9b89bd95d1ab73e202020-11-24T23:48:07ZengHindawi LimitedCanadian Journal of Gastroenterology0835-79001989-01-01339810210.1155/1989/806380Antibodies to Cardiolipin in Patients with Primary Biliary CirrhosisJohn Verrier Jones0Dianne P. Mosher1Edith Jones2C. Noel Williams3Dickran Malatjalian4Roland I. Carr5Mervat Mansour6Departments of Medicine and Pathology, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, CanadaDepartments of Medicine and Pathology, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, CanadaDepartments of Medicine and Pathology, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, CanadaDepartments of Medicine and Pathology, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, CanadaDepartments of Medicine and Pathology, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, CanadaDepartments of Medicine and Pathology, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, CanadaDepartments of Medicine and Pathology, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, CanadaAntibodies to cardiolipin have been recognized in up to 65% of patients with systemic lupus erythematosus. It has been claimed that they are significantly associated with intravascular thrombosis and with obstetrical complications. Thus far they have been found to be less prevalent in other diseases. Because of the high concentration of cardiolipin in mitochondrial membranes and the presence of antimitochondrial antibodies in patients with primary biliary cirrhosis, the authors investigated the prevalence of antibodies to cardiolipin in a group of 31 patients with primary biliary cirrhosis. lt was found that the prevalence and levels of anticardiolipin antibodies of lgG and lgA isotype are as high in patients with primary biliary cirrhosis as in 35 consecutive patients with systemic lupus erythematosus. None of the patients with primary biliary cirrhosis gave any history of venous or arterial thrombosis. The rate of miscarriage was less than that reported for the general population. The availability for study of a second group of patients with high levels of anticardiolipin antibodies should make it possible to determine whether the association of these antibodies with thrombosis and fetal wastage in patients with systemic lupus erythematosus is a direct relation ship or an epiphenomenon.http://dx.doi.org/10.1155/1989/806380
collection DOAJ
language English
format Article
sources DOAJ
author John Verrier Jones
Dianne P. Mosher
Edith Jones
C. Noel Williams
Dickran Malatjalian
Roland I. Carr
Mervat Mansour
spellingShingle John Verrier Jones
Dianne P. Mosher
Edith Jones
C. Noel Williams
Dickran Malatjalian
Roland I. Carr
Mervat Mansour
Antibodies to Cardiolipin in Patients with Primary Biliary Cirrhosis
Canadian Journal of Gastroenterology
author_facet John Verrier Jones
Dianne P. Mosher
Edith Jones
C. Noel Williams
Dickran Malatjalian
Roland I. Carr
Mervat Mansour
author_sort John Verrier Jones
title Antibodies to Cardiolipin in Patients with Primary Biliary Cirrhosis
title_short Antibodies to Cardiolipin in Patients with Primary Biliary Cirrhosis
title_full Antibodies to Cardiolipin in Patients with Primary Biliary Cirrhosis
title_fullStr Antibodies to Cardiolipin in Patients with Primary Biliary Cirrhosis
title_full_unstemmed Antibodies to Cardiolipin in Patients with Primary Biliary Cirrhosis
title_sort antibodies to cardiolipin in patients with primary biliary cirrhosis
publisher Hindawi Limited
series Canadian Journal of Gastroenterology
issn 0835-7900
publishDate 1989-01-01
description Antibodies to cardiolipin have been recognized in up to 65% of patients with systemic lupus erythematosus. It has been claimed that they are significantly associated with intravascular thrombosis and with obstetrical complications. Thus far they have been found to be less prevalent in other diseases. Because of the high concentration of cardiolipin in mitochondrial membranes and the presence of antimitochondrial antibodies in patients with primary biliary cirrhosis, the authors investigated the prevalence of antibodies to cardiolipin in a group of 31 patients with primary biliary cirrhosis. lt was found that the prevalence and levels of anticardiolipin antibodies of lgG and lgA isotype are as high in patients with primary biliary cirrhosis as in 35 consecutive patients with systemic lupus erythematosus. None of the patients with primary biliary cirrhosis gave any history of venous or arterial thrombosis. The rate of miscarriage was less than that reported for the general population. The availability for study of a second group of patients with high levels of anticardiolipin antibodies should make it possible to determine whether the association of these antibodies with thrombosis and fetal wastage in patients with systemic lupus erythematosus is a direct relation ship or an epiphenomenon.
url http://dx.doi.org/10.1155/1989/806380
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