HIV-1 Integrase-DNA Recognition Mechanisms

Integration of a reverse transcribed DNA copy of the HIV viral genome into the host chromosome is essential for virus replication. This process is catalyzed by the virally encoded protein integrase. The catalytic activities, which involve DNA cutting and joining steps, have been recapitulated in vit...

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Main Authors:	Mamuka Kvaratskhelia, Ari Katz, Nikolozi Shkriabai, Jocelyn O. Eidahl, Christopher J. McKee, Jacques J. Kessl
Format:	Article
Language:	English
Published:	MDPI AG 2009-11-01
Series:	Viruses
Subjects:	HIV retroviruses DNA integrase crosslinking footprinting
Online Access:	http://www.mdpi.com/1999-4915/1/3/713/

id	doaj-f358cbf67f2c43f8aa48b368a2e64b13
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spelling	doaj-f358cbf67f2c43f8aa48b368a2e64b132020-11-25T01:43:02ZengMDPI AGViruses1999-49152009-11-011371373610.3390/v1030713HIV-1 Integrase-DNA Recognition MechanismsMamuka KvaratskheliaAri KatzNikolozi ShkriabaiJocelyn O. EidahlChristopher J. McKeeJacques J. KesslIntegration of a reverse transcribed DNA copy of the HIV viral genome into the host chromosome is essential for virus replication. This process is catalyzed by the virally encoded protein integrase. The catalytic activities, which involve DNA cutting and joining steps, have been recapitulated in vitro using recombinant integrase and synthetic DNA substrates. Biochemical and biophysical studies of these model reactions have been pivotal in advancing our understanding of mechanistic details for how IN interacts with viral and target DNAs, and are the focus of the present review. http://www.mdpi.com/1999-4915/1/3/713/HIVretrovirusesDNAintegrasecrosslinkingfootprinting
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mamuka Kvaratskhelia Ari Katz Nikolozi Shkriabai Jocelyn O. Eidahl Christopher J. McKee Jacques J. Kessl
spellingShingle	Mamuka Kvaratskhelia Ari Katz Nikolozi Shkriabai Jocelyn O. Eidahl Christopher J. McKee Jacques J. Kessl HIV-1 Integrase-DNA Recognition Mechanisms Viruses HIV retroviruses DNA integrase crosslinking footprinting
author_facet	Mamuka Kvaratskhelia Ari Katz Nikolozi Shkriabai Jocelyn O. Eidahl Christopher J. McKee Jacques J. Kessl
author_sort	Mamuka Kvaratskhelia
title	HIV-1 Integrase-DNA Recognition Mechanisms
title_short	HIV-1 Integrase-DNA Recognition Mechanisms
title_full	HIV-1 Integrase-DNA Recognition Mechanisms
title_fullStr	HIV-1 Integrase-DNA Recognition Mechanisms
title_full_unstemmed	HIV-1 Integrase-DNA Recognition Mechanisms
title_sort	hiv-1 integrase-dna recognition mechanisms
publisher	MDPI AG
series	Viruses
issn	1999-4915
publishDate	2009-11-01
description	Integration of a reverse transcribed DNA copy of the HIV viral genome into the host chromosome is essential for virus replication. This process is catalyzed by the virally encoded protein integrase. The catalytic activities, which involve DNA cutting and joining steps, have been recapitulated in vitro using recombinant integrase and synthetic DNA substrates. Biochemical and biophysical studies of these model reactions have been pivotal in advancing our understanding of mechanistic details for how IN interacts with viral and target DNAs, and are the focus of the present review.
topic	HIV retroviruses DNA integrase crosslinking footprinting
url	http://www.mdpi.com/1999-4915/1/3/713/
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HIV-1 Integrase-DNA Recognition Mechanisms

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