A model of DNA damage response activation at stalled replication forks by SPRTN

A model of DNA damage response activation at stalled replication forks by SPRTN

The process of DNA replication is threatened by many factors, including DNA lesions, and machineries acting as obstacles. Here we discuss and speculate on a recently proposed mechanism of DNA damage response activation in response to lesions that challenge the progression of DNA replication forks.

Bibliographic Details
Main Authors: Christopher Bruhn, Marco Foiani
Format: Article
Language:English
Published: Nature Publishing Group 2019-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13610-7
id doaj-f367c6151ba84697a0a594a8dd42fb3f
record_format Article
spelling doaj-f367c6151ba84697a0a594a8dd42fb3f2021-05-11T11:51:16ZengNature Publishing GroupNature Communications2041-17232019-12-011011310.1038/s41467-019-13610-7A model of DNA damage response activation at stalled replication forks by SPRTNChristopher Bruhn0Marco Foiani1IFOM (Istituto FIRC di Oncologia Molecolare)IFOM (Istituto FIRC di Oncologia Molecolare)The process of DNA replication is threatened by many factors, including DNA lesions, and machineries acting as obstacles. Here we discuss and speculate on a recently proposed mechanism of DNA damage response activation in response to lesions that challenge the progression of DNA replication forks.https://doi.org/10.1038/s41467-019-13610-7
collection DOAJ
language English
format Article
sources DOAJ
author Christopher Bruhn
Marco Foiani
spellingShingle Christopher Bruhn
Marco Foiani
A model of DNA damage response activation at stalled replication forks by SPRTN
Nature Communications
author_facet Christopher Bruhn
Marco Foiani
author_sort Christopher Bruhn
title A model of DNA damage response activation at stalled replication forks by SPRTN
title_short A model of DNA damage response activation at stalled replication forks by SPRTN
title_full A model of DNA damage response activation at stalled replication forks by SPRTN
title_fullStr A model of DNA damage response activation at stalled replication forks by SPRTN
title_full_unstemmed A model of DNA damage response activation at stalled replication forks by SPRTN
title_sort model of dna damage response activation at stalled replication forks by sprtn
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-12-01
description The process of DNA replication is threatened by many factors, including DNA lesions, and machineries acting as obstacles. Here we discuss and speculate on a recently proposed mechanism of DNA damage response activation in response to lesions that challenge the progression of DNA replication forks.
url https://doi.org/10.1038/s41467-019-13610-7
work_keys_str_mv AT christopherbruhn amodelofdnadamageresponseactivationatstalledreplicationforksbysprtn
AT marcofoiani amodelofdnadamageresponseactivationatstalledreplicationforksbysprtn
AT christopherbruhn modelofdnadamageresponseactivationatstalledreplicationforksbysprtn
AT marcofoiani modelofdnadamageresponseactivationatstalledreplicationforksbysprtn
_version_ 1721445908809252864

Similar Items