The effect on the availability of manganese and zinc ions for pathogenic bacteria
Manganese and zinc play a role in the infectious process, wherein a change in the concentration of manganese and zinc can significantly impact the disease course. Bacterial pathogens utilize manganese ions as a protector that protects the organism from compounds of radicals generated by macroorganis...
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doaj-f368c424feff4763a9c6eda1b76248fb2020-11-24T22:31:24ZengPublishing House ZaslavskyZdorovʹe Rebenka2224-05512307-11682018-09-0113660961510.22141/2224-0551.13.6.2018.143168143168The effect on the availability of manganese and zinc ions for pathogenic bacteriaА.Е. Abaturov0Т.А. Kryuchko1State Institution “Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine”, Dnipro, UkraineHSEIU “Ukrainian Medical Stomatological Academy”, Poltava, UkraineManganese and zinc play a role in the infectious process, wherein a change in the concentration of manganese and zinc can significantly impact the disease course. Bacterial pathogens utilize manganese ions as a protector that protects the organism from compounds of radicals generated by macroorganisms in infectious process. Therefore, a change in the level of supply of pathogenic bacteria with these microelements can impact the disease course. The macroorganism in the infectious process limits the availability of manganese for bacterial pathogens with the help of calprotectin, which can chelate Mn2+, Zn2+, competing with bacterial pathogens for these elements. Calprotectin is released at very high concentrations during the formation of neutrophilic extracellular traps, wherein calprotectin inhibits bacterial growth by sequestering zinc. However, calprotectin can promote the development of pneumonia caused by bacteria Streptococcus pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa. The effectiveness of the use of zinc preparations for various infectious diseases is widely studied, wherein the use of such preparations prevents the development of acute respiratory infections and contributes to milder course, including severe pneumonia in children.http://childshealth.zaslavsky.com.ua/article/view/143168pneumoniamanganesezincpathogenic bacteriazinc drugs |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
А.Е. Abaturov Т.А. Kryuchko |
spellingShingle |
А.Е. Abaturov Т.А. Kryuchko The effect on the availability of manganese and zinc ions for pathogenic bacteria Zdorovʹe Rebenka pneumonia manganese zinc pathogenic bacteria zinc drugs |
author_facet |
А.Е. Abaturov Т.А. Kryuchko |
author_sort |
А.Е. Abaturov |
title |
The effect on the availability of manganese and zinc ions for pathogenic bacteria |
title_short |
The effect on the availability of manganese and zinc ions for pathogenic bacteria |
title_full |
The effect on the availability of manganese and zinc ions for pathogenic bacteria |
title_fullStr |
The effect on the availability of manganese and zinc ions for pathogenic bacteria |
title_full_unstemmed |
The effect on the availability of manganese and zinc ions for pathogenic bacteria |
title_sort |
effect on the availability of manganese and zinc ions for pathogenic bacteria |
publisher |
Publishing House Zaslavsky |
series |
Zdorovʹe Rebenka |
issn |
2224-0551 2307-1168 |
publishDate |
2018-09-01 |
description |
Manganese and zinc play a role in the infectious process, wherein a change in the concentration of manganese and zinc can significantly impact the disease course. Bacterial pathogens utilize manganese ions as a protector that protects the organism from compounds of radicals generated by macroorganisms in infectious process. Therefore, a change in the level of supply of pathogenic bacteria with these microelements can impact the disease course. The macroorganism in the infectious process limits the availability of manganese for bacterial pathogens with the help of calprotectin, which can chelate Mn2+, Zn2+, competing with bacterial pathogens for these elements. Calprotectin is released at very high concentrations during the formation of neutrophilic extracellular traps, wherein calprotectin inhibits bacterial growth by sequestering zinc. However, calprotectin can promote the development of pneumonia caused by bacteria Streptococcus pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa. The effectiveness of the use of zinc preparations for various infectious diseases is widely studied, wherein the use of such preparations prevents the development of acute respiratory infections and contributes to milder course, including severe pneumonia in children. |
topic |
pneumonia manganese zinc pathogenic bacteria zinc drugs |
url |
http://childshealth.zaslavsky.com.ua/article/view/143168 |
work_keys_str_mv |
AT aeabaturov theeffectontheavailabilityofmanganeseandzincionsforpathogenicbacteria AT takryuchko theeffectontheavailabilityofmanganeseandzincionsforpathogenicbacteria AT aeabaturov effectontheavailabilityofmanganeseandzincionsforpathogenicbacteria AT takryuchko effectontheavailabilityofmanganeseandzincionsforpathogenicbacteria |
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