Is it necessary to use tobramycin-dexamethasone eye ointment prophylactically in eyes at the end of intraocular surgery?
Abstract Background There are no data available regarding the complications associated with using antibiotic ointment at the end of intraocular surgery. This study aimed to explore the necessity of using ocular tobramycin-dexamethasone prophylactically at the end of intraocular surgery. Methods This...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2020-05-01
|
Series: | BMC Ophthalmology |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12886-020-01476-z |
id |
doaj-f36b29641a3d47bd941caf42f1ba66df |
---|---|
record_format |
Article |
spelling |
doaj-f36b29641a3d47bd941caf42f1ba66df2020-11-25T03:53:08ZengBMCBMC Ophthalmology1471-24152020-05-012011610.1186/s12886-020-01476-zIs it necessary to use tobramycin-dexamethasone eye ointment prophylactically in eyes at the end of intraocular surgery?Wei Zhang0Han Han1Kang Feng2Xiaohong Wang3Mei Du4Xiangda Meng5Yuanyuan Liu6Bo Huang7Rodrigo Brant8Hua Yan9Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Clinical College of Ophthalmology Tianjin Medical UniversityDepartment of Ophthalmology, Tianjin Medical University General HospitalDepartment of Ophthalmology, Peking University Third HospitalLaboratory of Molecular Ophthalmology, Tianjin Medical UniversityLaboratory of Molecular Ophthalmology, Tianjin Medical UniversityDepartment of Ophthalmology, Tianjin Medical University General HospitalDepartment of Ophthalmology, Tianjin Medical University General HospitalDepartment of Ophthalmology, University of Mississippi Medical CenterDepartment of Ophthalmology and Visual Sciences, Federal University of São PauloDepartment of Ophthalmology, Tianjin Medical University General HospitalAbstract Background There are no data available regarding the complications associated with using antibiotic ointment at the end of intraocular surgery. This study aimed to explore the necessity of using ocular tobramycin-dexamethasone prophylactically at the end of intraocular surgery. Methods This was a retrospective cohort study of patients who received intraocular surgery at Tianjin Medical University General Hospital from January 2015 to December 2017. The patients were grouped according to whether they received tobramycin-dexamethasone eye ointment or not after surgery. The Tobramycin dexamethasone eye ointment was sampled to observe bacterial contamination pathogens at 0.5, 1, 1.5, 2, 2.5, 3, 6, 8, 24, 36, 48, 72, and 168 h after being opened. Results A total of 3811 eyes in 3811 patients (mean age of 63 ± 12 years) were included: 2397 eyes that received prophylactic tobramycin-dexamethasone eye ointment and 1414 eyes that did not. The overall rate of endophthalmitis was 0.08% (3/3811) in our study, all in the eye ointment group (0.12%, 3/2397); no patients developed endophthalmitis in the non-ointment group (0%, 0/1414)(P = 0.184). The anterior chamber reactions 1 day after surgery were more serious in the eye ointment group compared with the non-ointment group (all P < 0.05), but there were no statistically significant differences at 1 month postoperatively (all P > 0.05). The contamination rate was 0% at all time points over 7 days. Conclusion We did not observe a statistically significant difference in the incidence of endophthalmitis in patients with or without prophylactic tobramycin-dexamethasone eye ointment. And tobramycin-dexamethasone eye ointment seemed to increase some side effects such as eye secretions increasing and foreign body feeling.http://link.springer.com/article/10.1186/s12886-020-01476-zVitrectomyCataract extractionGlaucomaAntibiotics, prophylacticEndophthalmitis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wei Zhang Han Han Kang Feng Xiaohong Wang Mei Du Xiangda Meng Yuanyuan Liu Bo Huang Rodrigo Brant Hua Yan |
spellingShingle |
Wei Zhang Han Han Kang Feng Xiaohong Wang Mei Du Xiangda Meng Yuanyuan Liu Bo Huang Rodrigo Brant Hua Yan Is it necessary to use tobramycin-dexamethasone eye ointment prophylactically in eyes at the end of intraocular surgery? BMC Ophthalmology Vitrectomy Cataract extraction Glaucoma Antibiotics, prophylactic Endophthalmitis |
author_facet |
Wei Zhang Han Han Kang Feng Xiaohong Wang Mei Du Xiangda Meng Yuanyuan Liu Bo Huang Rodrigo Brant Hua Yan |
author_sort |
Wei Zhang |
title |
Is it necessary to use tobramycin-dexamethasone eye ointment prophylactically in eyes at the end of intraocular surgery? |
title_short |
Is it necessary to use tobramycin-dexamethasone eye ointment prophylactically in eyes at the end of intraocular surgery? |
title_full |
Is it necessary to use tobramycin-dexamethasone eye ointment prophylactically in eyes at the end of intraocular surgery? |
title_fullStr |
Is it necessary to use tobramycin-dexamethasone eye ointment prophylactically in eyes at the end of intraocular surgery? |
title_full_unstemmed |
Is it necessary to use tobramycin-dexamethasone eye ointment prophylactically in eyes at the end of intraocular surgery? |
title_sort |
is it necessary to use tobramycin-dexamethasone eye ointment prophylactically in eyes at the end of intraocular surgery? |
publisher |
BMC |
series |
BMC Ophthalmology |
issn |
1471-2415 |
publishDate |
2020-05-01 |
description |
Abstract Background There are no data available regarding the complications associated with using antibiotic ointment at the end of intraocular surgery. This study aimed to explore the necessity of using ocular tobramycin-dexamethasone prophylactically at the end of intraocular surgery. Methods This was a retrospective cohort study of patients who received intraocular surgery at Tianjin Medical University General Hospital from January 2015 to December 2017. The patients were grouped according to whether they received tobramycin-dexamethasone eye ointment or not after surgery. The Tobramycin dexamethasone eye ointment was sampled to observe bacterial contamination pathogens at 0.5, 1, 1.5, 2, 2.5, 3, 6, 8, 24, 36, 48, 72, and 168 h after being opened. Results A total of 3811 eyes in 3811 patients (mean age of 63 ± 12 years) were included: 2397 eyes that received prophylactic tobramycin-dexamethasone eye ointment and 1414 eyes that did not. The overall rate of endophthalmitis was 0.08% (3/3811) in our study, all in the eye ointment group (0.12%, 3/2397); no patients developed endophthalmitis in the non-ointment group (0%, 0/1414)(P = 0.184). The anterior chamber reactions 1 day after surgery were more serious in the eye ointment group compared with the non-ointment group (all P < 0.05), but there were no statistically significant differences at 1 month postoperatively (all P > 0.05). The contamination rate was 0% at all time points over 7 days. Conclusion We did not observe a statistically significant difference in the incidence of endophthalmitis in patients with or without prophylactic tobramycin-dexamethasone eye ointment. And tobramycin-dexamethasone eye ointment seemed to increase some side effects such as eye secretions increasing and foreign body feeling. |
topic |
Vitrectomy Cataract extraction Glaucoma Antibiotics, prophylactic Endophthalmitis |
url |
http://link.springer.com/article/10.1186/s12886-020-01476-z |
work_keys_str_mv |
AT weizhang isitnecessarytousetobramycindexamethasoneeyeointmentprophylacticallyineyesattheendofintraocularsurgery AT hanhan isitnecessarytousetobramycindexamethasoneeyeointmentprophylacticallyineyesattheendofintraocularsurgery AT kangfeng isitnecessarytousetobramycindexamethasoneeyeointmentprophylacticallyineyesattheendofintraocularsurgery AT xiaohongwang isitnecessarytousetobramycindexamethasoneeyeointmentprophylacticallyineyesattheendofintraocularsurgery AT meidu isitnecessarytousetobramycindexamethasoneeyeointmentprophylacticallyineyesattheendofintraocularsurgery AT xiangdameng isitnecessarytousetobramycindexamethasoneeyeointmentprophylacticallyineyesattheendofintraocularsurgery AT yuanyuanliu isitnecessarytousetobramycindexamethasoneeyeointmentprophylacticallyineyesattheendofintraocularsurgery AT bohuang isitnecessarytousetobramycindexamethasoneeyeointmentprophylacticallyineyesattheendofintraocularsurgery AT rodrigobrant isitnecessarytousetobramycindexamethasoneeyeointmentprophylacticallyineyesattheendofintraocularsurgery AT huayan isitnecessarytousetobramycindexamethasoneeyeointmentprophylacticallyineyesattheendofintraocularsurgery |
_version_ |
1724479785171681280 |