A study of diffusion tensor imaging of median nerve in diabetic peripheral neuropathy
Abstract Objective To evaluate the role of diffusion tensor imaging (DTI) in the evaluation of diabetic peripheral neuropathy (DPN) compared to clinical scores and nerve conduction studies (NCS). Patients and methods We included 30 patients with diabetes mellitus complaining of neuropathy symptoms a...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
SpringerOpen
2020-04-01
|
Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s41983-020-00172-5 |
id |
doaj-f370dd5ddd2a419ca14d1987ac393096 |
---|---|
record_format |
Article |
spelling |
doaj-f370dd5ddd2a419ca14d1987ac3930962020-11-25T03:00:27ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292020-04-015611810.1186/s41983-020-00172-5A study of diffusion tensor imaging of median nerve in diabetic peripheral neuropathyRamy Edward0Ahmed M. Abdelalim1Amal S. Ashour2Lamia Afifi3Aussan Al-Athwari4Department of Radiodiagnosis, Cairo UniversityDepartment of Neurology, Cairo UniversityDepartment of Neurology, Cairo UniversityClinical Neurophysiology Unit, Cairo UniversityDepartment of Neurology, Cairo UniversityAbstract Objective To evaluate the role of diffusion tensor imaging (DTI) in the evaluation of diabetic peripheral neuropathy (DPN) compared to clinical scores and nerve conduction studies (NCS). Patients and methods We included 30 patients with diabetes mellitus complaining of neuropathy symptoms and 15 healthy volunteers. All subjects underwent evaluation using 1.5-T DTI of median nerves and NCS. Patients underwent clinical evaluation using the Neuropathy Deficit Score (NDS), Neuropathy Impairment Score in the Lower Limbs (NIS-LL), and Diabetic Neuropathy Examination (DNE) score. Results We found statistically significant differences between healthy volunteers and patients in fractional anisotropy (FA) of the distal segment (P = 0.016) and whole median nerve (P = 0.024), apparent diffusion coefficient (ADC) of proximal (P = 0.027) and distal (P < 0.001) segments, and whole median nerve (P = 0.019). Distal segment FA was significantly correlated with NDS (P = 0.003), DNEs (P = 0.003), sensory amplitude (P = 0.048), and motor CV (P = 0.020). Distal segment ADC was significantly correlated with NDS (P = 0.007), NIS-LL (P = 0.003), DNEs (P = 0.01), and sensory amplitude (P = 0.032). The best cut-off value of distal segment for FA was 0.45 (87% sensitivity, 80% specificity) and of distal segment ADC was 1.217 (80% sensitivity and specificity). Conclusions Our results suggest that 1.5-T DTI examination of the median nerve can provide useful non-invasive information in patients with DPN. Trial registration ClinicalTrials.gov , NCT03934970 . Registered on May 1, 2019http://link.springer.com/article/10.1186/s41983-020-00172-5Diabetic neuropathyDTIFAADCClinical scoresNCS |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ramy Edward Ahmed M. Abdelalim Amal S. Ashour Lamia Afifi Aussan Al-Athwari |
spellingShingle |
Ramy Edward Ahmed M. Abdelalim Amal S. Ashour Lamia Afifi Aussan Al-Athwari A study of diffusion tensor imaging of median nerve in diabetic peripheral neuropathy The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Diabetic neuropathy DTI FA ADC Clinical scores NCS |
author_facet |
Ramy Edward Ahmed M. Abdelalim Amal S. Ashour Lamia Afifi Aussan Al-Athwari |
author_sort |
Ramy Edward |
title |
A study of diffusion tensor imaging of median nerve in diabetic peripheral neuropathy |
title_short |
A study of diffusion tensor imaging of median nerve in diabetic peripheral neuropathy |
title_full |
A study of diffusion tensor imaging of median nerve in diabetic peripheral neuropathy |
title_fullStr |
A study of diffusion tensor imaging of median nerve in diabetic peripheral neuropathy |
title_full_unstemmed |
A study of diffusion tensor imaging of median nerve in diabetic peripheral neuropathy |
title_sort |
study of diffusion tensor imaging of median nerve in diabetic peripheral neuropathy |
publisher |
SpringerOpen |
series |
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
issn |
1687-8329 |
publishDate |
2020-04-01 |
description |
Abstract Objective To evaluate the role of diffusion tensor imaging (DTI) in the evaluation of diabetic peripheral neuropathy (DPN) compared to clinical scores and nerve conduction studies (NCS). Patients and methods We included 30 patients with diabetes mellitus complaining of neuropathy symptoms and 15 healthy volunteers. All subjects underwent evaluation using 1.5-T DTI of median nerves and NCS. Patients underwent clinical evaluation using the Neuropathy Deficit Score (NDS), Neuropathy Impairment Score in the Lower Limbs (NIS-LL), and Diabetic Neuropathy Examination (DNE) score. Results We found statistically significant differences between healthy volunteers and patients in fractional anisotropy (FA) of the distal segment (P = 0.016) and whole median nerve (P = 0.024), apparent diffusion coefficient (ADC) of proximal (P = 0.027) and distal (P < 0.001) segments, and whole median nerve (P = 0.019). Distal segment FA was significantly correlated with NDS (P = 0.003), DNEs (P = 0.003), sensory amplitude (P = 0.048), and motor CV (P = 0.020). Distal segment ADC was significantly correlated with NDS (P = 0.007), NIS-LL (P = 0.003), DNEs (P = 0.01), and sensory amplitude (P = 0.032). The best cut-off value of distal segment for FA was 0.45 (87% sensitivity, 80% specificity) and of distal segment ADC was 1.217 (80% sensitivity and specificity). Conclusions Our results suggest that 1.5-T DTI examination of the median nerve can provide useful non-invasive information in patients with DPN. Trial registration ClinicalTrials.gov , NCT03934970 . Registered on May 1, 2019 |
topic |
Diabetic neuropathy DTI FA ADC Clinical scores NCS |
url |
http://link.springer.com/article/10.1186/s41983-020-00172-5 |
work_keys_str_mv |
AT ramyedward astudyofdiffusiontensorimagingofmediannerveindiabeticperipheralneuropathy AT ahmedmabdelalim astudyofdiffusiontensorimagingofmediannerveindiabeticperipheralneuropathy AT amalsashour astudyofdiffusiontensorimagingofmediannerveindiabeticperipheralneuropathy AT lamiaafifi astudyofdiffusiontensorimagingofmediannerveindiabeticperipheralneuropathy AT aussanalathwari astudyofdiffusiontensorimagingofmediannerveindiabeticperipheralneuropathy AT ramyedward studyofdiffusiontensorimagingofmediannerveindiabeticperipheralneuropathy AT ahmedmabdelalim studyofdiffusiontensorimagingofmediannerveindiabeticperipheralneuropathy AT amalsashour studyofdiffusiontensorimagingofmediannerveindiabeticperipheralneuropathy AT lamiaafifi studyofdiffusiontensorimagingofmediannerveindiabeticperipheralneuropathy AT aussanalathwari studyofdiffusiontensorimagingofmediannerveindiabeticperipheralneuropathy |
_version_ |
1724698079124258816 |