Intercellular cGAMP transmission induces innate immune activation and tissue inflammation in Trex1 deficiency

Intercellular cGAMP transmission induces innate immune activation and tissue inflammation in Trex1 deficiency

Summary: Intercellular transmission of the second messenger 2′,3′-cGAMP, synthesized by the viral DNA sensor cGAMP synthase (cGAS), is a potent mode of bystander activation during host defense. However, whether this mechanism also contributes to cGAS-dependent autoimmunity remains unknown. Here, usi...

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Bibliographic Details
Main Authors: Bianca B. Jütte, Calvin Krollmann, Kevin Cieslak, Ruth-Miriam Koerber, Peter Boor, Claus M. Graef, Eva Bartok, Mirko Wagner, Thomas Carell, Jennifer Landsberg, Pia Aymans, Jörg Wenzel, Peter Brossart, Lino L. Teichmann
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:iScience
Subjects:
Immunology
Immunity
Immune response
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221008014

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