Some New Pyrido[2,3-d ]pyridimines and their Nucleoside of Biological Importance
Chalcones (I) reacted with malanonitrile and ammonium acetate yielded 2-amino-3-cyano-4,6-disubstituted pyridines (II) in excellent yield. 4-Amino-5,7-disubstituted pyrido [2,3-d]pyrimidine-2(1H)-thiones (III), 4-amino-5,7-disubstituted pyrido[2,3-d]pyrimidines (IV) and 4-imino-3,5,7-trisubstituted...
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doaj-f37274da11bc4857ad1208b8f98d5ece2020-11-25T00:49:19ZengHindawi LimitedE-Journal of Chemistry0973-49452090-98102010-01-017S1S85S9210.1155/2010/812567Some New Pyrido[2,3-d ]pyridimines and their Nucleoside of Biological ImportanceSangeeta Tiwari0Ashok K. Yadav1A. K. Mishra2Department of Chemistry, University of Rajasthan, Jaipur-302004, IndiaDepartment of Chemistry, University of Rajasthan, Jaipur-302004, IndiaDepartment of Chemistry, University of Rajasthan, Jaipur-302004, IndiaChalcones (I) reacted with malanonitrile and ammonium acetate yielded 2-amino-3-cyano-4,6-disubstituted pyridines (II) in excellent yield. 4-Amino-5,7-disubstituted pyrido [2,3-d]pyrimidine-2(1H)-thiones (III), 4-amino-5,7-disubstituted pyrido[2,3-d]pyrimidines (IV) and 4-imino-3,5,7-trisubstituted pyrido[2,3-d]pyrimidin-2(1H)-ones (V) have been synthesized by the condensation of compound (II) with thiourea, formamide and arylisocynate respectively. The ribofuranosides viz. 4-amino-5,7-disubstituted-1- [2',3',5'-tri-o-benzoyl- β , D-ribofuranosyl]pyrido[2,3-d]pyrimidine-2-(1H)-thiones (VI) and 4-imino-3,5,7- trisubstituted-1- [2',3',5'-tri-o-benzoyl-β , D-ribofuranosyl] pyrido [2,3-d] pyrimidine-2(1H)-one (VII) were synthesized by converting compounds III and V to trimethylsilyl derivative in situ by reacting them with hexamethyldisilazane to give corresponding ribofuranosides with β-D-ribofuranose-1-acetate-2,3,5-tribenzoate. Compounds III-V and their ribofuranosides have been screened for antimicrobial and antifungal evaluations.http://dx.doi.org/10.1155/2010/812567 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sangeeta Tiwari Ashok K. Yadav A. K. Mishra |
spellingShingle |
Sangeeta Tiwari Ashok K. Yadav A. K. Mishra Some New Pyrido[2,3-d ]pyridimines and their Nucleoside of Biological Importance E-Journal of Chemistry |
author_facet |
Sangeeta Tiwari Ashok K. Yadav A. K. Mishra |
author_sort |
Sangeeta Tiwari |
title |
Some New Pyrido[2,3-d ]pyridimines and their Nucleoside of Biological Importance |
title_short |
Some New Pyrido[2,3-d ]pyridimines and their Nucleoside of Biological Importance |
title_full |
Some New Pyrido[2,3-d ]pyridimines and their Nucleoside of Biological Importance |
title_fullStr |
Some New Pyrido[2,3-d ]pyridimines and their Nucleoside of Biological Importance |
title_full_unstemmed |
Some New Pyrido[2,3-d ]pyridimines and their Nucleoside of Biological Importance |
title_sort |
some new pyrido[2,3-d ]pyridimines and their nucleoside of biological importance |
publisher |
Hindawi Limited |
series |
E-Journal of Chemistry |
issn |
0973-4945 2090-9810 |
publishDate |
2010-01-01 |
description |
Chalcones (I) reacted with malanonitrile and ammonium acetate yielded 2-amino-3-cyano-4,6-disubstituted pyridines (II) in excellent yield. 4-Amino-5,7-disubstituted pyrido [2,3-d]pyrimidine-2(1H)-thiones (III), 4-amino-5,7-disubstituted pyrido[2,3-d]pyrimidines (IV) and 4-imino-3,5,7-trisubstituted pyrido[2,3-d]pyrimidin-2(1H)-ones (V) have been synthesized by the condensation of compound (II) with thiourea, formamide and arylisocynate respectively. The ribofuranosides viz. 4-amino-5,7-disubstituted-1- [2',3',5'-tri-o-benzoyl- β , D-ribofuranosyl]pyrido[2,3-d]pyrimidine-2-(1H)-thiones (VI) and 4-imino-3,5,7- trisubstituted-1- [2',3',5'-tri-o-benzoyl-β , D-ribofuranosyl] pyrido [2,3-d] pyrimidine-2(1H)-one (VII) were synthesized by converting compounds III and V to trimethylsilyl derivative in situ by reacting them with hexamethyldisilazane to give corresponding ribofuranosides with β-D-ribofuranose-1-acetate-2,3,5-tribenzoate. Compounds III-V and their ribofuranosides have been screened for antimicrobial and antifungal evaluations. |
url |
http://dx.doi.org/10.1155/2010/812567 |
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