Construction of COX-2 short hairpin RNA expression vector and its inhibitory effect on hepatic fibrosis

Construction of COX-2 short hairpin RNA expression vector and its inhibitory effect on hepatic fibrosis

The aim of this study was to construct recombinant adenovirus vector carrying a short hairpin RNA (shRNA) that can exclusively target cyclooxygenase-2 (COX-2) gene expression and observe its inhibitory effect on hepatic fibrosis. We designed and synthesized three oligonucleotide sequences, and clone...

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Bibliographic Details
Main Authors: Ni Xie, Hong Wu Liao, Wen Sheng Ou, Xu Zhou, Yang Hu, Nian Fu, Xue Feng Yang, Duan-Fang Liao
Format: Article
Language:English
Published: Taylor & Francis Group 2018-05-01
Series:Biotechnology & Biotechnological Equipment
Subjects:
Cyclooxygenase-2
recombinant adenovirus vector
liver fibrosis
short hairpin RNA
Online Access:http://dx.doi.org/10.1080/13102818.2018.1431569

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