Systemic Lupus Erythematosus and Thyroid Autoimmunity
Most of the studies present in the literature show a high prevalence, and incidence, of new cases of hypothyroidism and autoimmune thyroiditis (AT) in systemic lupus erythematosus (SLE) patients, overall in female gender. A limited number of cases of Graves’ disease have been also reported in SLE pa...
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doaj-f37965b33fc04a4484c2c43add2b2ad32020-11-24T21:47:08ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922017-06-01810.3389/fendo.2017.00138273759Systemic Lupus Erythematosus and Thyroid AutoimmunitySilvia Martina Ferrari0Giusy Elia1Camilla Virili2Marco Centanni3Alessandro Antonelli4Poupak Fallahi5Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalyDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, “Sapienza” University of Rome, Latina, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, “Sapienza” University of Rome, Latina, ItalyDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalyDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalyMost of the studies present in the literature show a high prevalence, and incidence, of new cases of hypothyroidism and autoimmune thyroiditis (AT) in systemic lupus erythematosus (SLE) patients, overall in female gender. A limited number of cases of Graves’ disease have been also reported in SLE patients, in agreement with the higher prevalence of thyroid autoimmunity. It has been also demonstrated that a Th1 predominance is associated with AT in SLE patients. Furthermore, a higher prevalence of papillary thyroid cancer has been recently reported in SLE, in particular in the presence of thyroid autoimmunity. However, studies in larger number of SLE patients are needed to confirm findings about thyroid cancer. On the whole, data from literature strongly suggest that female SLE patients, with a high risk (a normal but at the higher limit thyroid-stimulating hormone value, positive antithyroid peroxidase antibodies, a hypoechoic pattern, and small thyroid), should undergo periodic thyroid function follow-up, and appropriate treatments when needed. A careful thyroid monitoring would be opportune during the follow-up of these patients.http://journal.frontiersin.org/article/10.3389/fendo.2017.00138/fullsystemic lupus erythematosusautoimmune thyroiditishypothyroidismGraves’ diseasethyroid cancerAbTPO |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Silvia Martina Ferrari Giusy Elia Camilla Virili Marco Centanni Alessandro Antonelli Poupak Fallahi |
spellingShingle |
Silvia Martina Ferrari Giusy Elia Camilla Virili Marco Centanni Alessandro Antonelli Poupak Fallahi Systemic Lupus Erythematosus and Thyroid Autoimmunity Frontiers in Endocrinology systemic lupus erythematosus autoimmune thyroiditis hypothyroidism Graves’ disease thyroid cancer AbTPO |
author_facet |
Silvia Martina Ferrari Giusy Elia Camilla Virili Marco Centanni Alessandro Antonelli Poupak Fallahi |
author_sort |
Silvia Martina Ferrari |
title |
Systemic Lupus Erythematosus and Thyroid Autoimmunity |
title_short |
Systemic Lupus Erythematosus and Thyroid Autoimmunity |
title_full |
Systemic Lupus Erythematosus and Thyroid Autoimmunity |
title_fullStr |
Systemic Lupus Erythematosus and Thyroid Autoimmunity |
title_full_unstemmed |
Systemic Lupus Erythematosus and Thyroid Autoimmunity |
title_sort |
systemic lupus erythematosus and thyroid autoimmunity |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Endocrinology |
issn |
1664-2392 |
publishDate |
2017-06-01 |
description |
Most of the studies present in the literature show a high prevalence, and incidence, of new cases of hypothyroidism and autoimmune thyroiditis (AT) in systemic lupus erythematosus (SLE) patients, overall in female gender. A limited number of cases of Graves’ disease have been also reported in SLE patients, in agreement with the higher prevalence of thyroid autoimmunity. It has been also demonstrated that a Th1 predominance is associated with AT in SLE patients. Furthermore, a higher prevalence of papillary thyroid cancer has been recently reported in SLE, in particular in the presence of thyroid autoimmunity. However, studies in larger number of SLE patients are needed to confirm findings about thyroid cancer. On the whole, data from literature strongly suggest that female SLE patients, with a high risk (a normal but at the higher limit thyroid-stimulating hormone value, positive antithyroid peroxidase antibodies, a hypoechoic pattern, and small thyroid), should undergo periodic thyroid function follow-up, and appropriate treatments when needed. A careful thyroid monitoring would be opportune during the follow-up of these patients. |
topic |
systemic lupus erythematosus autoimmune thyroiditis hypothyroidism Graves’ disease thyroid cancer AbTPO |
url |
http://journal.frontiersin.org/article/10.3389/fendo.2017.00138/full |
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