An RNA transport system in Candida albicans regulates hyphal morphology and invasive growth.
Localization of specific mRNAs is an important mechanism through which cells achieve polarity and direct asymmetric growth. Based on a framework established in Saccharomyces cerevisiae, we describe a She3-dependent RNA transport system in Candida albicans, a fungal pathogen of humans that grows as b...
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2009-09-01
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Series: | PLoS Genetics |
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doaj-f37a1516bfc34f43be54cf6a6ce5c2172020-11-25T01:26:49ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042009-09-0159e100066410.1371/journal.pgen.1000664An RNA transport system in Candida albicans regulates hyphal morphology and invasive growth.Sarah L ElsonSuzanne M NobleNorma V SolisScott G FillerAlexander D JohnsonLocalization of specific mRNAs is an important mechanism through which cells achieve polarity and direct asymmetric growth. Based on a framework established in Saccharomyces cerevisiae, we describe a She3-dependent RNA transport system in Candida albicans, a fungal pathogen of humans that grows as both budding (yeast) and filamentous (hyphal and pseudohyphal) forms. We identify a set of 40 mRNAs that are selectively transported to the buds of yeast-form cells and to the tips of hyphae, and we show that many of the genes encoded by these mRNAs contribute to hyphal development, as does the transport system itself. Although the basic system of mRNA transport is conserved between S. cerevisiae and C. albicans, we find that the cargo mRNAs have diverged considerably, implying that specific mRNAs can easily move in and out of transport control over evolutionary timescales. The differences in mRNA cargos likely reflect the distinct selective pressures acting on the two species.http://europepmc.org/articles/PMC2739428?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sarah L Elson Suzanne M Noble Norma V Solis Scott G Filler Alexander D Johnson |
spellingShingle |
Sarah L Elson Suzanne M Noble Norma V Solis Scott G Filler Alexander D Johnson An RNA transport system in Candida albicans regulates hyphal morphology and invasive growth. PLoS Genetics |
author_facet |
Sarah L Elson Suzanne M Noble Norma V Solis Scott G Filler Alexander D Johnson |
author_sort |
Sarah L Elson |
title |
An RNA transport system in Candida albicans regulates hyphal morphology and invasive growth. |
title_short |
An RNA transport system in Candida albicans regulates hyphal morphology and invasive growth. |
title_full |
An RNA transport system in Candida albicans regulates hyphal morphology and invasive growth. |
title_fullStr |
An RNA transport system in Candida albicans regulates hyphal morphology and invasive growth. |
title_full_unstemmed |
An RNA transport system in Candida albicans regulates hyphal morphology and invasive growth. |
title_sort |
rna transport system in candida albicans regulates hyphal morphology and invasive growth. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Genetics |
issn |
1553-7390 1553-7404 |
publishDate |
2009-09-01 |
description |
Localization of specific mRNAs is an important mechanism through which cells achieve polarity and direct asymmetric growth. Based on a framework established in Saccharomyces cerevisiae, we describe a She3-dependent RNA transport system in Candida albicans, a fungal pathogen of humans that grows as both budding (yeast) and filamentous (hyphal and pseudohyphal) forms. We identify a set of 40 mRNAs that are selectively transported to the buds of yeast-form cells and to the tips of hyphae, and we show that many of the genes encoded by these mRNAs contribute to hyphal development, as does the transport system itself. Although the basic system of mRNA transport is conserved between S. cerevisiae and C. albicans, we find that the cargo mRNAs have diverged considerably, implying that specific mRNAs can easily move in and out of transport control over evolutionary timescales. The differences in mRNA cargos likely reflect the distinct selective pressures acting on the two species. |
url |
http://europepmc.org/articles/PMC2739428?pdf=render |
work_keys_str_mv |
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