Metachronous Gastrointestinal Stromal Tumor and Acute Leukemia after Liver Transplantation for Cholangiocellular Carcinoma:Is There a Link

• Main Authors: Anna Mrzljak, Iva Košuta, Anita Škrtić, Ika Kardum-Skelin, Radovan Vrhovac
• Format: Article
• Language: English
• Published: Karger Publishers 2013-03-01
• Series: Case Reports in Oncology
• Subjects: Cholangiocellular carcinoma; Gastrointestinal stromal tumor; Liver transplantation; Acute leukemia
• Online Access: http://www.karger.com/Article/FullText/348817

The synchronous or metachronous coexistence of gastrointestinal stromal tumors (GISTs) with solid and hematologic neoplasms has been addressed in a non-transplant population. However, the association with primary hepatic neoplasms and leukemias is uncommon. Scarce data exist considering association of GISTs and other neoplasms in a transplant population where long-term immunosuppression carries the additional burden of de novo malignancy. We present a case of posttransplant metachronous GIST and acute biphenotypic leukemia in a patient transplanted for intrahepatic cholangiocellular carcinoma, emphasizing the possible link between mechanisms of carcinogenesis and influence of other factors upon their development.