Regulation of Human Breast Cancer by the Long Non-Coding RNA H19
Breast cancer is one of the most common causes of cancer related deaths in women. Despite the progress in early detection and use of new therapeutic targets associated with development of novel therapeutic options, breast cancer remains a major problem in public health. Indeed, even if the survival...
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doaj-f37c0921fcaa4cf8b17fb86d3a975d622020-11-24T21:04:31ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-11-011811231910.3390/ijms18112319ijms18112319Regulation of Human Breast Cancer by the Long Non-Coding RNA H19Jordan Collette0Xuefen Le Bourhis1Eric Adriaenssens2INSERM U908, 59655 Villeneuve d’Ascq, FranceINSERM U908, 59655 Villeneuve d’Ascq, FranceINSERM U908, 59655 Villeneuve d’Ascq, FranceBreast cancer is one of the most common causes of cancer related deaths in women. Despite the progress in early detection and use of new therapeutic targets associated with development of novel therapeutic options, breast cancer remains a major problem in public health. Indeed, even if the survival rate has improved for breast cancer patients, the number of recurrences within five years and the five-year relative survival rate in patients with metastasis remain dramatic. Thus, the discovery of new molecular actors involved in breast progression is essential to improve the management of this disease. Numerous data indicate that long non-coding RNA are implicated in breast cancer development. The oncofetal lncRNA H19 was the first RNA identified as a riboregulator. Studying of this lncRNA revealed its implication in both normal development and diseases. In this review, we summarize the different mechanisms of action of H19 in human breast cancer.https://www.mdpi.com/1422-0067/18/11/2319lncRNAH19breast cancernon-coding RNA |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jordan Collette Xuefen Le Bourhis Eric Adriaenssens |
spellingShingle |
Jordan Collette Xuefen Le Bourhis Eric Adriaenssens Regulation of Human Breast Cancer by the Long Non-Coding RNA H19 International Journal of Molecular Sciences lncRNA H19 breast cancer non-coding RNA |
author_facet |
Jordan Collette Xuefen Le Bourhis Eric Adriaenssens |
author_sort |
Jordan Collette |
title |
Regulation of Human Breast Cancer by the Long Non-Coding RNA H19 |
title_short |
Regulation of Human Breast Cancer by the Long Non-Coding RNA H19 |
title_full |
Regulation of Human Breast Cancer by the Long Non-Coding RNA H19 |
title_fullStr |
Regulation of Human Breast Cancer by the Long Non-Coding RNA H19 |
title_full_unstemmed |
Regulation of Human Breast Cancer by the Long Non-Coding RNA H19 |
title_sort |
regulation of human breast cancer by the long non-coding rna h19 |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2017-11-01 |
description |
Breast cancer is one of the most common causes of cancer related deaths in women. Despite the progress in early detection and use of new therapeutic targets associated with development of novel therapeutic options, breast cancer remains a major problem in public health. Indeed, even if the survival rate has improved for breast cancer patients, the number of recurrences within five years and the five-year relative survival rate in patients with metastasis remain dramatic. Thus, the discovery of new molecular actors involved in breast progression is essential to improve the management of this disease. Numerous data indicate that long non-coding RNA are implicated in breast cancer development. The oncofetal lncRNA H19 was the first RNA identified as a riboregulator. Studying of this lncRNA revealed its implication in both normal development and diseases. In this review, we summarize the different mechanisms of action of H19 in human breast cancer. |
topic |
lncRNA H19 breast cancer non-coding RNA |
url |
https://www.mdpi.com/1422-0067/18/11/2319 |
work_keys_str_mv |
AT jordancollette regulationofhumanbreastcancerbythelongnoncodingrnah19 AT xuefenlebourhis regulationofhumanbreastcancerbythelongnoncodingrnah19 AT ericadriaenssens regulationofhumanbreastcancerbythelongnoncodingrnah19 |
_version_ |
1716770829138657280 |