A Network Pharmacology Study on the Active Ingredients and Potential Targets of Tripterygium wilfordii Hook for Treatment of Rheumatoid Arthritis
Traditional Chinese medicine has specific effect on some chronic diseases in clinic, especially in rheumatic diseases. Tripterygium wilfordii Hook (TWH) is a traditional Chinese medicine commonly used in the treatment of rheumatoid arthritis (RA); the unique therapeutic effect has been confirmed by...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2019-01-01
|
Series: | Evidence-Based Complementary and Alternative Medicine |
Online Access: | http://dx.doi.org/10.1155/2019/5276865 |
id |
doaj-f381a1e252364520860baa1ebb0ca392 |
---|---|
record_format |
Article |
spelling |
doaj-f381a1e252364520860baa1ebb0ca3922020-11-25T02:01:06ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882019-01-01201910.1155/2019/52768655276865A Network Pharmacology Study on the Active Ingredients and Potential Targets of Tripterygium wilfordii Hook for Treatment of Rheumatoid ArthritisWei Hu0Wanjin Fu1Xin Wei2Yang Yang3Chao Lu4Zeyuan Liu5Department of Clinical Pharmacology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing, ChinaDepartment of Pharmacology, The Second Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Pharmacology, The Second Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Pharmacology, The Second Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Pharmacology, The Second Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Clinical Pharmacology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing, ChinaTraditional Chinese medicine has specific effect on some chronic diseases in clinic, especially in rheumatic diseases. Tripterygium wilfordii Hook (TWH) is a traditional Chinese medicine commonly used in the treatment of rheumatoid arthritis (RA); the unique therapeutic effect has been confirmed by a large number of research papers. TWH has many compounds that lead to its active compounds. However, the potential targets and pharmacological and molecular mechanism of its action treatment of rheumatic diseases are not entirely clear. Therefore, the network pharmacology approach is needed to further study and explore its treatment mechanism. We have successfully set up 10 networks, including four major networks and other networks. Four major networks include rheumatoid arthritis disease network, compound-compound target network of TWH, TWH compound target-rheumatoid arthritis disease network, and TWH-rheumatoid arthritis disease-mechanism network. Other networks consist of RA disease and TWH related targets clusters, biological processes, and pathways network. Our study successfully predicted, explained, and confirmed the TWH of RA disease molecular synergy and found the potential of RA related targets, cluster, biological process, and pathways. This study not only provides prompts to the researcher who explores pharmacological and biological molecular mechanism of TWH applying to RA disease, but also proves a feasible method for discovering potential activated compounds from Chinese herbs.http://dx.doi.org/10.1155/2019/5276865 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wei Hu Wanjin Fu Xin Wei Yang Yang Chao Lu Zeyuan Liu |
spellingShingle |
Wei Hu Wanjin Fu Xin Wei Yang Yang Chao Lu Zeyuan Liu A Network Pharmacology Study on the Active Ingredients and Potential Targets of Tripterygium wilfordii Hook for Treatment of Rheumatoid Arthritis Evidence-Based Complementary and Alternative Medicine |
author_facet |
Wei Hu Wanjin Fu Xin Wei Yang Yang Chao Lu Zeyuan Liu |
author_sort |
Wei Hu |
title |
A Network Pharmacology Study on the Active Ingredients and Potential Targets of Tripterygium wilfordii Hook for Treatment of Rheumatoid Arthritis |
title_short |
A Network Pharmacology Study on the Active Ingredients and Potential Targets of Tripterygium wilfordii Hook for Treatment of Rheumatoid Arthritis |
title_full |
A Network Pharmacology Study on the Active Ingredients and Potential Targets of Tripterygium wilfordii Hook for Treatment of Rheumatoid Arthritis |
title_fullStr |
A Network Pharmacology Study on the Active Ingredients and Potential Targets of Tripterygium wilfordii Hook for Treatment of Rheumatoid Arthritis |
title_full_unstemmed |
A Network Pharmacology Study on the Active Ingredients and Potential Targets of Tripterygium wilfordii Hook for Treatment of Rheumatoid Arthritis |
title_sort |
network pharmacology study on the active ingredients and potential targets of tripterygium wilfordii hook for treatment of rheumatoid arthritis |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2019-01-01 |
description |
Traditional Chinese medicine has specific effect on some chronic diseases in clinic, especially in rheumatic diseases. Tripterygium wilfordii Hook (TWH) is a traditional Chinese medicine commonly used in the treatment of rheumatoid arthritis (RA); the unique therapeutic effect has been confirmed by a large number of research papers. TWH has many compounds that lead to its active compounds. However, the potential targets and pharmacological and molecular mechanism of its action treatment of rheumatic diseases are not entirely clear. Therefore, the network pharmacology approach is needed to further study and explore its treatment mechanism. We have successfully set up 10 networks, including four major networks and other networks. Four major networks include rheumatoid arthritis disease network, compound-compound target network of TWH, TWH compound target-rheumatoid arthritis disease network, and TWH-rheumatoid arthritis disease-mechanism network. Other networks consist of RA disease and TWH related targets clusters, biological processes, and pathways network. Our study successfully predicted, explained, and confirmed the TWH of RA disease molecular synergy and found the potential of RA related targets, cluster, biological process, and pathways. This study not only provides prompts to the researcher who explores pharmacological and biological molecular mechanism of TWH applying to RA disease, but also proves a feasible method for discovering potential activated compounds from Chinese herbs. |
url |
http://dx.doi.org/10.1155/2019/5276865 |
work_keys_str_mv |
AT weihu anetworkpharmacologystudyontheactiveingredientsandpotentialtargetsoftripterygiumwilfordiihookfortreatmentofrheumatoidarthritis AT wanjinfu anetworkpharmacologystudyontheactiveingredientsandpotentialtargetsoftripterygiumwilfordiihookfortreatmentofrheumatoidarthritis AT xinwei anetworkpharmacologystudyontheactiveingredientsandpotentialtargetsoftripterygiumwilfordiihookfortreatmentofrheumatoidarthritis AT yangyang anetworkpharmacologystudyontheactiveingredientsandpotentialtargetsoftripterygiumwilfordiihookfortreatmentofrheumatoidarthritis AT chaolu anetworkpharmacologystudyontheactiveingredientsandpotentialtargetsoftripterygiumwilfordiihookfortreatmentofrheumatoidarthritis AT zeyuanliu anetworkpharmacologystudyontheactiveingredientsandpotentialtargetsoftripterygiumwilfordiihookfortreatmentofrheumatoidarthritis AT weihu networkpharmacologystudyontheactiveingredientsandpotentialtargetsoftripterygiumwilfordiihookfortreatmentofrheumatoidarthritis AT wanjinfu networkpharmacologystudyontheactiveingredientsandpotentialtargetsoftripterygiumwilfordiihookfortreatmentofrheumatoidarthritis AT xinwei networkpharmacologystudyontheactiveingredientsandpotentialtargetsoftripterygiumwilfordiihookfortreatmentofrheumatoidarthritis AT yangyang networkpharmacologystudyontheactiveingredientsandpotentialtargetsoftripterygiumwilfordiihookfortreatmentofrheumatoidarthritis AT chaolu networkpharmacologystudyontheactiveingredientsandpotentialtargetsoftripterygiumwilfordiihookfortreatmentofrheumatoidarthritis AT zeyuanliu networkpharmacologystudyontheactiveingredientsandpotentialtargetsoftripterygiumwilfordiihookfortreatmentofrheumatoidarthritis |
_version_ |
1724958782175313920 |