Deciphering Signaling Pathway Networks to Understand the Molecular Mechanisms of Metformin Action.
A drug exerts its effects typically through a signal transduction cascade, which is non-linear and involves intertwined networks of multiple signaling pathways. Construction of such a signaling pathway network (SPNetwork) can enable identification of novel drug targets and deep understanding of drug...
Main Authors: | Jingchun Sun, Min Zhao, Peilin Jia, Lily Wang, Yonghui Wu, Carissa Iverson, Yubo Zhou, Erica Bowton, Dan M Roden, Joshua C Denny, Melinda C Aldrich, Hua Xu, Zhongming Zhao |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-06-01
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Series: | PLoS Computational Biology |
Online Access: | http://europepmc.org/articles/PMC4470683?pdf=render |
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