The Clinical Significance of Programmed Death-1, Regulatory T Cells and Myeloid Derived Suppressor Cells in Patients with Nontuberculous Mycobacteria-Lung Disease
Background: Increasing expression of programmed death-1 (PD-1) in patients with nontuberculous mycobacteria lung disease (NTM-LD) has been reported, but its role in clinical characteristics and outcomes remains unclear. Methods: We enrolled 96 participants, including 46 with <i>Mycobacterium a...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-05-01
|
Series: | Journal of Clinical Medicine |
Subjects: | |
Online Access: | https://www.mdpi.com/2077-0383/8/5/736 |
id |
doaj-f38a232913b9491bae4bc76320f18e27 |
---|---|
record_format |
Article |
spelling |
doaj-f38a232913b9491bae4bc76320f18e272020-11-25T00:52:59ZengMDPI AGJournal of Clinical Medicine2077-03832019-05-018573610.3390/jcm8050736jcm8050736The Clinical Significance of Programmed Death-1, Regulatory T Cells and Myeloid Derived Suppressor Cells in Patients with Nontuberculous Mycobacteria-Lung DiseaseChin-Chung Shu0Sheng-Wei Pan1Jia-Yih Feng2Jann-Yuan Wang3Yu-Jiun Chan4Chong-Jen Yu5Wei-Juin Su6Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, TaiwanDepartment of Chest Medicine, Taipei Veterans General Hospital, Taipei 112, TaiwanDepartment of Chest Medicine, Taipei Veterans General Hospital, Taipei 112, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital, Taipei 100, TaiwanDivision of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei 112, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital, Taipei 100, TaiwanDepartment of Chest Medicine, Taipei Veterans General Hospital, Taipei 112, TaiwanBackground: Increasing expression of programmed death-1 (PD-1) in patients with nontuberculous mycobacteria lung disease (NTM-LD) has been reported, but its role in clinical characteristics and outcomes remains unclear. Methods: We enrolled 96 participants, including 46 with <i>Mycobacterium avium</i> complex (MAC)-LD, 23 with <i>M. abscessus</i> (MAB)-LD, and 27 controls. We measured expressions of PD-1, cytotoxic T-lymphocyte antigen-4 (CTLA-4) and regulatory T (Treg) cells on CD4<sup>+</sup> lymphocytes and myeloid-derived suppressor cells (MDSCs) and analyzed their association with clinical features and radiographic outcomes. Results: The percentage of PD-1 on CD4<sup>+</sup>(PD-1<sup>+</sup>CD4<sup>+</sup>) lymphocytes and MDSCs were higher in the MAC-LD group than the controls. There were no intergroup differences regarding CTLA-4<sup>+</sup>CD4<sup>+</sup> lymphocytes. Higher PD-1<sup>+</sup>CD4<sup>+</sup> lymphocytes were found in <i>M. intracellulare-</i> and <i>M. avium</i>-LD than in other MAC-LD. Positive sputum acid-fast stains and fibrocavitary radiographic lesions were correlated with elevated PD-1<sup>+</sup>CD4<sup>+</sup> lymphocytes and Treg cells. The percentage of PD-1<sup>+</sup>CD4<sup>+</sup> lymphocytes at the initial and 2 months of follow-up significantly predicted subsequent radiographic progression. Conclusion: As markers of immune tolerance, PD-1<sup>+</sup>CD4<sup>+</sup> lymphocytes and MDSCs were higher in MAC-LD patients. The levels of PD-1<sup>+</sup>CD4<sup>+</sup> and Treg cells were correlated with high mycobacteria bacilli burden in NTM-LD. Monitoring the expressions of PD-1<sup>+</sup>CD4<sup>+</sup> lymphocytes may predict radiographic progression.https://www.mdpi.com/2077-0383/8/5/736cytotoxic T-lymphocyte antigen-4<i>Mycobacterium avium</i> complex<i>Mycobacterium abscessus</i>myeloid derived suppressor cellsnontuberculous mycobacteriaprogrammed death-1regulatory T cells |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chin-Chung Shu Sheng-Wei Pan Jia-Yih Feng Jann-Yuan Wang Yu-Jiun Chan Chong-Jen Yu Wei-Juin Su |
spellingShingle |
Chin-Chung Shu Sheng-Wei Pan Jia-Yih Feng Jann-Yuan Wang Yu-Jiun Chan Chong-Jen Yu Wei-Juin Su The Clinical Significance of Programmed Death-1, Regulatory T Cells and Myeloid Derived Suppressor Cells in Patients with Nontuberculous Mycobacteria-Lung Disease Journal of Clinical Medicine cytotoxic T-lymphocyte antigen-4 <i>Mycobacterium avium</i> complex <i>Mycobacterium abscessus</i> myeloid derived suppressor cells nontuberculous mycobacteria programmed death-1 regulatory T cells |
author_facet |
Chin-Chung Shu Sheng-Wei Pan Jia-Yih Feng Jann-Yuan Wang Yu-Jiun Chan Chong-Jen Yu Wei-Juin Su |
author_sort |
Chin-Chung Shu |
title |
The Clinical Significance of Programmed Death-1, Regulatory T Cells and Myeloid Derived Suppressor Cells in Patients with Nontuberculous Mycobacteria-Lung Disease |
title_short |
The Clinical Significance of Programmed Death-1, Regulatory T Cells and Myeloid Derived Suppressor Cells in Patients with Nontuberculous Mycobacteria-Lung Disease |
title_full |
The Clinical Significance of Programmed Death-1, Regulatory T Cells and Myeloid Derived Suppressor Cells in Patients with Nontuberculous Mycobacteria-Lung Disease |
title_fullStr |
The Clinical Significance of Programmed Death-1, Regulatory T Cells and Myeloid Derived Suppressor Cells in Patients with Nontuberculous Mycobacteria-Lung Disease |
title_full_unstemmed |
The Clinical Significance of Programmed Death-1, Regulatory T Cells and Myeloid Derived Suppressor Cells in Patients with Nontuberculous Mycobacteria-Lung Disease |
title_sort |
clinical significance of programmed death-1, regulatory t cells and myeloid derived suppressor cells in patients with nontuberculous mycobacteria-lung disease |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2019-05-01 |
description |
Background: Increasing expression of programmed death-1 (PD-1) in patients with nontuberculous mycobacteria lung disease (NTM-LD) has been reported, but its role in clinical characteristics and outcomes remains unclear. Methods: We enrolled 96 participants, including 46 with <i>Mycobacterium avium</i> complex (MAC)-LD, 23 with <i>M. abscessus</i> (MAB)-LD, and 27 controls. We measured expressions of PD-1, cytotoxic T-lymphocyte antigen-4 (CTLA-4) and regulatory T (Treg) cells on CD4<sup>+</sup> lymphocytes and myeloid-derived suppressor cells (MDSCs) and analyzed their association with clinical features and radiographic outcomes. Results: The percentage of PD-1 on CD4<sup>+</sup>(PD-1<sup>+</sup>CD4<sup>+</sup>) lymphocytes and MDSCs were higher in the MAC-LD group than the controls. There were no intergroup differences regarding CTLA-4<sup>+</sup>CD4<sup>+</sup> lymphocytes. Higher PD-1<sup>+</sup>CD4<sup>+</sup> lymphocytes were found in <i>M. intracellulare-</i> and <i>M. avium</i>-LD than in other MAC-LD. Positive sputum acid-fast stains and fibrocavitary radiographic lesions were correlated with elevated PD-1<sup>+</sup>CD4<sup>+</sup> lymphocytes and Treg cells. The percentage of PD-1<sup>+</sup>CD4<sup>+</sup> lymphocytes at the initial and 2 months of follow-up significantly predicted subsequent radiographic progression. Conclusion: As markers of immune tolerance, PD-1<sup>+</sup>CD4<sup>+</sup> lymphocytes and MDSCs were higher in MAC-LD patients. The levels of PD-1<sup>+</sup>CD4<sup>+</sup> and Treg cells were correlated with high mycobacteria bacilli burden in NTM-LD. Monitoring the expressions of PD-1<sup>+</sup>CD4<sup>+</sup> lymphocytes may predict radiographic progression. |
topic |
cytotoxic T-lymphocyte antigen-4 <i>Mycobacterium avium</i> complex <i>Mycobacterium abscessus</i> myeloid derived suppressor cells nontuberculous mycobacteria programmed death-1 regulatory T cells |
url |
https://www.mdpi.com/2077-0383/8/5/736 |
work_keys_str_mv |
AT chinchungshu theclinicalsignificanceofprogrammeddeath1regulatorytcellsandmyeloidderivedsuppressorcellsinpatientswithnontuberculousmycobacterialungdisease AT shengweipan theclinicalsignificanceofprogrammeddeath1regulatorytcellsandmyeloidderivedsuppressorcellsinpatientswithnontuberculousmycobacterialungdisease AT jiayihfeng theclinicalsignificanceofprogrammeddeath1regulatorytcellsandmyeloidderivedsuppressorcellsinpatientswithnontuberculousmycobacterialungdisease AT jannyuanwang theclinicalsignificanceofprogrammeddeath1regulatorytcellsandmyeloidderivedsuppressorcellsinpatientswithnontuberculousmycobacterialungdisease AT yujiunchan theclinicalsignificanceofprogrammeddeath1regulatorytcellsandmyeloidderivedsuppressorcellsinpatientswithnontuberculousmycobacterialungdisease AT chongjenyu theclinicalsignificanceofprogrammeddeath1regulatorytcellsandmyeloidderivedsuppressorcellsinpatientswithnontuberculousmycobacterialungdisease AT weijuinsu theclinicalsignificanceofprogrammeddeath1regulatorytcellsandmyeloidderivedsuppressorcellsinpatientswithnontuberculousmycobacterialungdisease AT chinchungshu clinicalsignificanceofprogrammeddeath1regulatorytcellsandmyeloidderivedsuppressorcellsinpatientswithnontuberculousmycobacterialungdisease AT shengweipan clinicalsignificanceofprogrammeddeath1regulatorytcellsandmyeloidderivedsuppressorcellsinpatientswithnontuberculousmycobacterialungdisease AT jiayihfeng clinicalsignificanceofprogrammeddeath1regulatorytcellsandmyeloidderivedsuppressorcellsinpatientswithnontuberculousmycobacterialungdisease AT jannyuanwang clinicalsignificanceofprogrammeddeath1regulatorytcellsandmyeloidderivedsuppressorcellsinpatientswithnontuberculousmycobacterialungdisease AT yujiunchan clinicalsignificanceofprogrammeddeath1regulatorytcellsandmyeloidderivedsuppressorcellsinpatientswithnontuberculousmycobacterialungdisease AT chongjenyu clinicalsignificanceofprogrammeddeath1regulatorytcellsandmyeloidderivedsuppressorcellsinpatientswithnontuberculousmycobacterialungdisease AT weijuinsu clinicalsignificanceofprogrammeddeath1regulatorytcellsandmyeloidderivedsuppressorcellsinpatientswithnontuberculousmycobacterialungdisease |
_version_ |
1725239864038785024 |