Estrogens in Hepatocellular Carcinoma: Friends or Foes?
Estrogens are recognized as key players in physiological regulation of various, classical and non-classical, target organs, and tissues, including liver development, homeostasis, and function. On the other hand, multiple, though dispersed, experimental evidence is highly suggestive for the implicati...
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MDPI AG
2021-04-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/9/2085 |
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doaj-f38d47c5518b4bd185ecd8bb31d626cd2021-04-26T23:00:39ZengMDPI AGCancers2072-66942021-04-01132085208510.3390/cancers13092085Estrogens in Hepatocellular Carcinoma: Friends or Foes?Giuseppe Carruba0Servizio di Internazionalizzazione e Ricerca Sanitaria (SIRS), Azienda di Rilievo Nazionale e di Alta Specializzazione (ARNAS)-Civico, Di Cristina, Benfratelli—Palermo, Piazza N. Leotta 2, 90127 Palermo, ItalyEstrogens are recognized as key players in physiological regulation of various, classical and non-classical, target organs, and tissues, including liver development, homeostasis, and function. On the other hand, multiple, though dispersed, experimental evidence is highly suggestive for the implication of estrogen in development and progression of hepatocellular carcinoma. In this paper, data from our own studies and the current literature are reviewed to help understanding this apparent discrepancy.https://www.mdpi.com/2072-6694/13/9/2085liverestrogenaromataseestrogen receptorsamphiregulinADAM17 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Giuseppe Carruba |
| spellingShingle |
Giuseppe Carruba Estrogens in Hepatocellular Carcinoma: Friends or Foes? Cancers liver estrogen aromatase estrogen receptors amphiregulin ADAM17 |
| author_facet |
Giuseppe Carruba |
| author_sort |
Giuseppe Carruba |
| title |
Estrogens in Hepatocellular Carcinoma: Friends or Foes? |
| title_short |
Estrogens in Hepatocellular Carcinoma: Friends or Foes? |
| title_full |
Estrogens in Hepatocellular Carcinoma: Friends or Foes? |
| title_fullStr |
Estrogens in Hepatocellular Carcinoma: Friends or Foes? |
| title_full_unstemmed |
Estrogens in Hepatocellular Carcinoma: Friends or Foes? |
| title_sort |
estrogens in hepatocellular carcinoma: friends or foes? |
| publisher |
MDPI AG |
| series |
Cancers |
| issn |
2072-6694 |
| publishDate |
2021-04-01 |
| description |
Estrogens are recognized as key players in physiological regulation of various, classical and non-classical, target organs, and tissues, including liver development, homeostasis, and function. On the other hand, multiple, though dispersed, experimental evidence is highly suggestive for the implication of estrogen in development and progression of hepatocellular carcinoma. In this paper, data from our own studies and the current literature are reviewed to help understanding this apparent discrepancy. |
| topic |
liver estrogen aromatase estrogen receptors amphiregulin ADAM17 |
| url |
https://www.mdpi.com/2072-6694/13/9/2085 |
| work_keys_str_mv |
AT giuseppecarruba estrogensinhepatocellularcarcinomafriendsorfoes |
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1721507419095302144 |