Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population
Racial inequalities are observed for different diseases and are mainly caused by differences in socioeconomic status between ethnoracial groups. Genetic factors have also been implicated, and recently, several studies have investigated the association between biogeographical ancestry (BGA) and compl...
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Elsevier
2018-04-01
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Series: | SSM: Population Health |
Online Access: | http://www.sciencedirect.com/science/article/pii/S235282731730174X |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Thiago Magalhães da Silva Rosemeire L. Fiaccone Fernanda S.G. Kehdy Eduardo Tarazona-Santos Laura C. Rodrigues Gustavo N.O. Costa Camila A. Figueiredo Neuza Maria Alcantara-Neves Maurício L. Barreto |
spellingShingle |
Thiago Magalhães da Silva Rosemeire L. Fiaccone Fernanda S.G. Kehdy Eduardo Tarazona-Santos Laura C. Rodrigues Gustavo N.O. Costa Camila A. Figueiredo Neuza Maria Alcantara-Neves Maurício L. Barreto Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population SSM: Population Health |
author_facet |
Thiago Magalhães da Silva Rosemeire L. Fiaccone Fernanda S.G. Kehdy Eduardo Tarazona-Santos Laura C. Rodrigues Gustavo N.O. Costa Camila A. Figueiredo Neuza Maria Alcantara-Neves Maurício L. Barreto |
author_sort |
Thiago Magalhães da Silva |
title |
Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population |
title_short |
Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population |
title_full |
Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population |
title_fullStr |
Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population |
title_full_unstemmed |
Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population |
title_sort |
biogeographical ancestry is associated with socioenvironmental conditions and infections in a latin american urban population |
publisher |
Elsevier |
series |
SSM: Population Health |
issn |
2352-8273 |
publishDate |
2018-04-01 |
description |
Racial inequalities are observed for different diseases and are mainly caused by differences in socioeconomic status between ethnoracial groups. Genetic factors have also been implicated, and recently, several studies have investigated the association between biogeographical ancestry (BGA) and complex diseases. However, the role of BGA as a proxy for non-genetic health determinants has been little investigated. Similarly, studies comparing the association of BGA and self-reported skin colour with these determinants are scarce. Here, we report the association of BGA and self-reported skin colour with socioenvironmental conditions and infections. We studied 1246 children living in a Brazilian urban poor area. The BGA was estimated using 370,539 genome-wide autosomal markers. Standardised questionnaires were administered to the children’s guardians to evaluate socioenvironmental conditions. Infection (or pathogen exposure) was defined by the presence of positive serologic test results for IgG to seven pathogens (Toxocara spp, Toxoplasma gondii, Helicobacter pylori, and hepatitis A, herpes simplex, herpes zoster and Epstein-Barr viruses) and the presence of intestinal helminth eggs in stool samples (Ascaris lumbricoides and Trichiuris trichiura). African ancestry was negatively associated with maternal education and household income and positively associated with infections and variables, indicating poorer housing and living conditions. The self-reported skin colour was associated with infections only. In stratified analyses, the proportion of African ancestry was associated with most of the outcomes investigated, particularly among admixed individuals. In conclusion, BGA was associated with socioenvironmental conditions and infections even in a low-income and highly admixed population, capturing differences that self-reported skin colour miss. Importantly, our findings suggest caution in interpreting significant associations between BGA and diseases as indicative of the genetic factors involved. Keywords: Biogeographical ancestry, Racial inequalities, Socioeconomic status, Infections |
url |
http://www.sciencedirect.com/science/article/pii/S235282731730174X |
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doaj-f38e300e8cf248f6880a65ceb191e44a2020-11-24T22:01:27ZengElsevierSSM: Population Health2352-82732018-04-014301306Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban populationThiago Magalhães da Silva0Rosemeire L. Fiaccone1Fernanda S.G. Kehdy2Eduardo Tarazona-Santos3Laura C. Rodrigues4Gustavo N.O. Costa5Camila A. Figueiredo6Neuza Maria Alcantara-Neves7Maurício L. Barreto8Institute of Collective Health, Federal University of Bahia, Salvador, Bahia, Brazil; Departamento de Ciências Biológicas, Universidade Estadual do Sudoeste da Bahia, Jequié 45206-190, Bahia, Brazil; Corresponding author at: Departamento de Ciências Biológicas, Universidade Estadual do Sudoeste da Bahia, Jequié 45206-190, Bahia, Brazil.Departamento de Estatística, Instituto de Matemática, Universidade Federal da Bahia, Salvador, Bahia, Brazil; Center of Data and Knowledge Integration for Health, Instituto Gonçalo Muniz, Fundação Osvaldo Cruz, Salvador, BrazilLaboratório de Hanseníase, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, BrazilDepartamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, BrazilDepartment of Infectious Disease Epidemiology, Faculty of Epidemiology, London School of Hygiene and Tropical Medicine, London, United KingdomInstitute of Collective Health, Federal University of Bahia, Salvador, Bahia, Brazil; Center of Data and Knowledge Integration for Health, Instituto Gonçalo Muniz, Fundação Osvaldo Cruz, Salvador, BrazilInstituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Bahia, BrazilInstituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Bahia, BrazilInstitute of Collective Health, Federal University of Bahia, Salvador, Bahia, Brazil; Center of Data and Knowledge Integration for Health, Instituto Gonçalo Muniz, Fundação Osvaldo Cruz, Salvador, BrazilRacial inequalities are observed for different diseases and are mainly caused by differences in socioeconomic status between ethnoracial groups. Genetic factors have also been implicated, and recently, several studies have investigated the association between biogeographical ancestry (BGA) and complex diseases. However, the role of BGA as a proxy for non-genetic health determinants has been little investigated. Similarly, studies comparing the association of BGA and self-reported skin colour with these determinants are scarce. Here, we report the association of BGA and self-reported skin colour with socioenvironmental conditions and infections. We studied 1246 children living in a Brazilian urban poor area. The BGA was estimated using 370,539 genome-wide autosomal markers. Standardised questionnaires were administered to the children’s guardians to evaluate socioenvironmental conditions. Infection (or pathogen exposure) was defined by the presence of positive serologic test results for IgG to seven pathogens (Toxocara spp, Toxoplasma gondii, Helicobacter pylori, and hepatitis A, herpes simplex, herpes zoster and Epstein-Barr viruses) and the presence of intestinal helminth eggs in stool samples (Ascaris lumbricoides and Trichiuris trichiura). African ancestry was negatively associated with maternal education and household income and positively associated with infections and variables, indicating poorer housing and living conditions. The self-reported skin colour was associated with infections only. In stratified analyses, the proportion of African ancestry was associated with most of the outcomes investigated, particularly among admixed individuals. In conclusion, BGA was associated with socioenvironmental conditions and infections even in a low-income and highly admixed population, capturing differences that self-reported skin colour miss. Importantly, our findings suggest caution in interpreting significant associations between BGA and diseases as indicative of the genetic factors involved. Keywords: Biogeographical ancestry, Racial inequalities, Socioeconomic status, Infectionshttp://www.sciencedirect.com/science/article/pii/S235282731730174X |