Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo.
Amyotrophic lateral sclerosis (ALS) is a late onset and progressive motor neuron disease. Mutations in the gene coding for fused in sarcoma/translocated in liposarcoma (FUS) are responsible for some cases of both familial and sporadic forms of ALS. The mechanism through which mutations of FUS result...
Main Authors: | Chiara Scaramuzzino, John Monaghan, Carmelo Milioto, Nicholas A Lanson, Astha Maltare, Tanya Aggarwal, Ian Casci, Frank O Fackelmayer, Maria Pennuto, Udai Bhan Pandey |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3631215?pdf=render |
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