A dual synergistic of curcumin and gelatin on thermal-responsive hydrogel based on Chitosan-P123 in wound healing application
This study aimed to fabricate the potential therapeutic scaffold to efficiently and safely fastening skin wound healing. A biocompatible grafting polymer-based thermal sensitive hybrid hydrogel (Chitosan-P123, CP) containing gelatin and curcumin was designed to be suitable stiffness for tissue regen...
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doaj-f39382a73477457a8d91269e2c9e990d2021-05-20T07:38:32ZengElsevierBiomedicine & Pharmacotherapy0753-33222019-09-01117A dual synergistic of curcumin and gelatin on thermal-responsive hydrogel based on Chitosan-P123 in wound healing applicationLyna Pham0Le Hang Dang1Minh Dung Truong2Thi Hiep Nguyen3Ly Le4Van Thu Le5Nguyen Dang Nam6Long Giang Bach7Van Toan Nguyen8Ngoc Quyen Tran9Institute of Research and Development, Duy Tan University, Da Nang City, 550000, Viet Nam; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Hochiminh City, 700000, Viet NamInstitute of Applied Materials Science, Vietnam Academy of Science and Technology, Hochiminh City, 700000, Viet Nam; International University, National Universities in Hochiminh, Hochiminh City, 700000, Viet NamAjou University Medical Center, Ajou University, 5 Wonchon, Yeoungtong, Suwon, 443-749, Republic of KoreaInternational University, National Universities in Hochiminh, Hochiminh City, 700000, Viet NamInternational University, National Universities in Hochiminh, Hochiminh City, 700000, Viet NamInstitute of Applied Materials Science, Vietnam Academy of Science and Technology, Hochiminh City, 700000, Viet Nam; Graduate University of Science and Technology Viet Nam, Vietnam Academy of Science and Technology, Hochiminh City, 700000, Viet NamInstitute of Research and Development, Duy Tan University, Da Nang City, 550000, Viet NamNTT Hi-Tech Institute, Nguyen Tat Thanh University, 300A Nguyen Tat Thanh, Ward 13 district 4, Ho Chi Minh city, 700000, Viet Nam; Corresponding author.Graduate University of Science and Technology Viet Nam, Vietnam Academy of Science and Technology, Hochiminh City, 700000, Viet Nam; Ba Ria-Vung Tau University, 80 Truong Cong Dinh, Ward 3, Vung Tau City, 78000, Viet NamInstitute of Research and Development, Duy Tan University, Da Nang City, 550000, Viet Nam; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Hochiminh City, 700000, Viet Nam; Graduate University of Science and Technology Viet Nam, Vietnam Academy of Science and Technology, Hochiminh City, 700000, Viet Nam; Corresponding author at: Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Hochiminh City, 700000, Viet NamThis study aimed to fabricate the potential therapeutic scaffold to efficiently and safely fastening skin wound healing. A biocompatible grafting polymer-based thermal sensitive hybrid hydrogel (Chitosan-P123, CP) containing gelatin and curcumin was designed to be suitable stiffness for tissue regeneration. A detailed in the rheological study found that the encapsulated agents induced the change in the stiffness of the hydrogel from the hard to the soft. Especial, the thermally induced phase transition of CP hydrogel was governed by the participant of gelatin rather than curcumin. For example, at 25 wt% gelatin, CP hydrogel exhibited a unique gel–sol-gel transition following the function of temperature. Moreover, in vitro investigation revealed that the hybrid hydrogel provides the capacity of especially induced curcumin release with a sustainable rate as well as the excellent biocompatibility scaffold. Altogether with in vivo study, the hybrid hydrogel highlighted the advance of the dual synergistic of curcumin and gelatin in development of smart scaffold system, which promoted the efficacy in the regeneration of the structure and the barrier's function of damaged skin such as wound or skin cancer.http://www.sciencedirect.com/science/article/pii/S0753332219319171Thermosensitive hydrogelChitosan-Pluronic P123Dual loadingWound healing |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lyna Pham Le Hang Dang Minh Dung Truong Thi Hiep Nguyen Ly Le Van Thu Le Nguyen Dang Nam Long Giang Bach Van Toan Nguyen Ngoc Quyen Tran |
spellingShingle |
Lyna Pham Le Hang Dang Minh Dung Truong Thi Hiep Nguyen Ly Le Van Thu Le Nguyen Dang Nam Long Giang Bach Van Toan Nguyen Ngoc Quyen Tran A dual synergistic of curcumin and gelatin on thermal-responsive hydrogel based on Chitosan-P123 in wound healing application Biomedicine & Pharmacotherapy Thermosensitive hydrogel Chitosan-Pluronic P123 Dual loading Wound healing |
author_facet |
Lyna Pham Le Hang Dang Minh Dung Truong Thi Hiep Nguyen Ly Le Van Thu Le Nguyen Dang Nam Long Giang Bach Van Toan Nguyen Ngoc Quyen Tran |
author_sort |
Lyna Pham |
title |
A dual synergistic of curcumin and gelatin on thermal-responsive hydrogel based on Chitosan-P123 in wound healing application |
title_short |
A dual synergistic of curcumin and gelatin on thermal-responsive hydrogel based on Chitosan-P123 in wound healing application |
title_full |
A dual synergistic of curcumin and gelatin on thermal-responsive hydrogel based on Chitosan-P123 in wound healing application |
title_fullStr |
A dual synergistic of curcumin and gelatin on thermal-responsive hydrogel based on Chitosan-P123 in wound healing application |
title_full_unstemmed |
A dual synergistic of curcumin and gelatin on thermal-responsive hydrogel based on Chitosan-P123 in wound healing application |
title_sort |
dual synergistic of curcumin and gelatin on thermal-responsive hydrogel based on chitosan-p123 in wound healing application |
publisher |
Elsevier |
series |
Biomedicine & Pharmacotherapy |
issn |
0753-3322 |
publishDate |
2019-09-01 |
description |
This study aimed to fabricate the potential therapeutic scaffold to efficiently and safely fastening skin wound healing. A biocompatible grafting polymer-based thermal sensitive hybrid hydrogel (Chitosan-P123, CP) containing gelatin and curcumin was designed to be suitable stiffness for tissue regeneration. A detailed in the rheological study found that the encapsulated agents induced the change in the stiffness of the hydrogel from the hard to the soft. Especial, the thermally induced phase transition of CP hydrogel was governed by the participant of gelatin rather than curcumin. For example, at 25 wt% gelatin, CP hydrogel exhibited a unique gel–sol-gel transition following the function of temperature. Moreover, in vitro investigation revealed that the hybrid hydrogel provides the capacity of especially induced curcumin release with a sustainable rate as well as the excellent biocompatibility scaffold. Altogether with in vivo study, the hybrid hydrogel highlighted the advance of the dual synergistic of curcumin and gelatin in development of smart scaffold system, which promoted the efficacy in the regeneration of the structure and the barrier's function of damaged skin such as wound or skin cancer. |
topic |
Thermosensitive hydrogel Chitosan-Pluronic P123 Dual loading Wound healing |
url |
http://www.sciencedirect.com/science/article/pii/S0753332219319171 |
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