Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs

Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs

DNA double-strand breaks (DSBs) are deleterious lesions that are generated in response to ionizing radiation or replication fork collapse that can lead to genomic instability and cancer. Eukaryotes have evolved two major pathways, namely homologous recombination (HR) and non-homologous end joining (...

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Main Author: Roopa Thapar
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Molecules
Subjects:
DNA repair
long non-coding RNA
microRNA
DNA damage
double-strand breaks
NHEJ
HR
Online Access:https://www.mdpi.com/1420-3049/23/11/2789
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spelling doaj-f39d3b1d5b88469b901155bf90945ca02020-11-24T21:45:45ZengMDPI AGMolecules1420-30492018-10-012311278910.3390/molecules23112789molecules23112789Regulation of DNA Double-Strand Break Repair by Non-Coding RNAsRoopa Thapar0Department of Molecular and Cellular Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USADNA double-strand breaks (DSBs) are deleterious lesions that are generated in response to ionizing radiation or replication fork collapse that can lead to genomic instability and cancer. Eukaryotes have evolved two major pathways, namely homologous recombination (HR) and non-homologous end joining (NHEJ) to repair DSBs. Whereas the roles of protein-DNA interactions in HR and NHEJ have been fairly well defined, the functions of small and long non-coding RNAs and RNA-DNA hybrids in the DNA damage response is just beginning to be elucidated. This review summarizes recent discoveries on the identification of non-coding RNAs and RNA-mediated regulation of DSB repair.https://www.mdpi.com/1420-3049/23/11/2789DNA repairlong non-coding RNAmicroRNADNA damagedouble-strand breaksNHEJHR
collection DOAJ
language English
format Article
sources DOAJ
author Roopa Thapar
spellingShingle Roopa Thapar
Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs
Molecules
DNA repair
long non-coding RNA
microRNA
DNA damage
double-strand breaks
NHEJ
HR
author_facet Roopa Thapar
author_sort Roopa Thapar
title Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs
title_short Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs
title_full Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs
title_fullStr Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs
title_full_unstemmed Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs
title_sort regulation of dna double-strand break repair by non-coding rnas
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2018-10-01
description DNA double-strand breaks (DSBs) are deleterious lesions that are generated in response to ionizing radiation or replication fork collapse that can lead to genomic instability and cancer. Eukaryotes have evolved two major pathways, namely homologous recombination (HR) and non-homologous end joining (NHEJ) to repair DSBs. Whereas the roles of protein-DNA interactions in HR and NHEJ have been fairly well defined, the functions of small and long non-coding RNAs and RNA-DNA hybrids in the DNA damage response is just beginning to be elucidated. This review summarizes recent discoveries on the identification of non-coding RNAs and RNA-mediated regulation of DSB repair.
topic DNA repair
long non-coding RNA
microRNA
DNA damage
double-strand breaks
NHEJ
HR
url https://www.mdpi.com/1420-3049/23/11/2789
work_keys_str_mv AT roopathapar regulationofdnadoublestrandbreakrepairbynoncodingrnas
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