Paths for Improving Bevacizumab Available in 2018: The ADZT Regimen for Better Glioblastoma Treatment
During glioblastoma treatment, the pharmaceutical monoclonal antibody to vascular endothelial growth factor A, bevacizumab, has improved the quality of life and delayed progression for several months, but has not (or only marginally) prolonged overall survival. In 2017, several dramatic research pap...
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doaj-f3a0c9a299254b4383859b4bb80942cb2020-11-25T00:09:35ZengMDPI AGMedical Sciences2076-32712018-09-01648410.3390/medsci6040084medsci6040084Paths for Improving Bevacizumab Available in 2018: The ADZT Regimen for Better Glioblastoma TreatmentRichard E. Kast0IIAIGC Study Center, 22 Church Street, Burlington, VT 05401, USADuring glioblastoma treatment, the pharmaceutical monoclonal antibody to vascular endothelial growth factor A, bevacizumab, has improved the quality of life and delayed progression for several months, but has not (or only marginally) prolonged overall survival. In 2017, several dramatic research papers appeared that are crucial to our understanding of glioblastoma vis-a-vis the mode of action of bevacizumab. As a consequence of these papers, a new, potentially more effective treatment protocol can be built around bevacizumab. This is the ADZT regimen, where four old drugs are added to bevacizumab. These four drugs are apremilast, marketed to treat psoriasis, dapsone, marketed to treat Hansen’s disease, zonisamide, marketed to treat seizures, and telmisartan, marketed to treat hypertension. The ancillary attributes of each of these drugs have been shown to augment bevacizumab. This paper details the research data supporting this contention. Phase three testing of AZDT addition to bevacizumab is required to establish safety and effectiveness before general use.http://www.mdpi.com/2076-3271/6/4/84ADZT regimenapremilastbevacizumabcAMPdapsoneglioblastomatelmisartanTNF-alphazonisamide |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Richard E. Kast |
spellingShingle |
Richard E. Kast Paths for Improving Bevacizumab Available in 2018: The ADZT Regimen for Better Glioblastoma Treatment Medical Sciences ADZT regimen apremilast bevacizumab cAMP dapsone glioblastoma telmisartan TNF-alpha zonisamide |
author_facet |
Richard E. Kast |
author_sort |
Richard E. Kast |
title |
Paths for Improving Bevacizumab Available in 2018: The ADZT Regimen for Better Glioblastoma Treatment |
title_short |
Paths for Improving Bevacizumab Available in 2018: The ADZT Regimen for Better Glioblastoma Treatment |
title_full |
Paths for Improving Bevacizumab Available in 2018: The ADZT Regimen for Better Glioblastoma Treatment |
title_fullStr |
Paths for Improving Bevacizumab Available in 2018: The ADZT Regimen for Better Glioblastoma Treatment |
title_full_unstemmed |
Paths for Improving Bevacizumab Available in 2018: The ADZT Regimen for Better Glioblastoma Treatment |
title_sort |
paths for improving bevacizumab available in 2018: the adzt regimen for better glioblastoma treatment |
publisher |
MDPI AG |
series |
Medical Sciences |
issn |
2076-3271 |
publishDate |
2018-09-01 |
description |
During glioblastoma treatment, the pharmaceutical monoclonal antibody to vascular endothelial growth factor A, bevacizumab, has improved the quality of life and delayed progression for several months, but has not (or only marginally) prolonged overall survival. In 2017, several dramatic research papers appeared that are crucial to our understanding of glioblastoma vis-a-vis the mode of action of bevacizumab. As a consequence of these papers, a new, potentially more effective treatment protocol can be built around bevacizumab. This is the ADZT regimen, where four old drugs are added to bevacizumab. These four drugs are apremilast, marketed to treat psoriasis, dapsone, marketed to treat Hansen’s disease, zonisamide, marketed to treat seizures, and telmisartan, marketed to treat hypertension. The ancillary attributes of each of these drugs have been shown to augment bevacizumab. This paper details the research data supporting this contention. Phase three testing of AZDT addition to bevacizumab is required to establish safety and effectiveness before general use. |
topic |
ADZT regimen apremilast bevacizumab cAMP dapsone glioblastoma telmisartan TNF-alpha zonisamide |
url |
http://www.mdpi.com/2076-3271/6/4/84 |
work_keys_str_mv |
AT richardekast pathsforimprovingbevacizumabavailablein2018theadztregimenforbetterglioblastomatreatment |
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1725411064202395648 |