The Role Of The C-Reactive Protein and Procalcitonin in The Early Diagnosis Of Intraabdominal Infection in Critical Patients With A History of Gastrointestinal Surgery

• Main Authors: Mustafa Altınay, Surhan Çınar, Mustafa Akker, Hacer Şebnem Türk
• Format: Article
• Language: English
• Published: KARE Publishing 2019-01-01
• Series: Southern Clinics of Istanbul Eurasia
• Subjects: c-reactive protein; procalcitonin; intraabdominal infection; gastrointestinal surgery
• Online Access: https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=SCIE-37029

INTRODUCTION[|]The purpose of this study is to determine the roles of CRP and PCT in the intraabdominal infective complications of gastrointestinal surgery patients. [¤]METHODS[|]This study is a prospective,single-blinded study.The subjects were critical gastrointestinal system surgery patients who had been transferred to the intensive care unit.The patients' serum CRP and PCT levels were measured in the 1st, 24th, 48th and 72nd hours after surgery.Those patients with intraabdominal infections were recorded.[¤]RESULTS[|]The study includes 49 patients.Of these patients 38% developed intraabdominal infections and the mortality rate was 4%.It was observed that the PCT levels in particular were statistically very significant at the 48th and 72nd hours.The sensitivity and specificity of the CRP level at the postoperative 48th and 72nd hours were 78.9% and 70% respectively.The sensitivity and specificity of the PCT level were 73.7% and 96.7% respectively at the postoperative 48th hour, and 84.2% and 90% respectively at the 72nd hour. [¤]DISCUSSION AND CONCLUSION[|]The elevated serum PCT and CRP concentrations at the 48- and 72-hour markers are critical for the early diagnosis of the intraabdominal infections.The predictivity of postoperative PCT concentrations at the 48th and 72nd hours is higher regarding infective complications compared to CRP. [¤]