Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America.
BACKGROUND:Lung-function decline is one of the possible mechanisms leading to Chronic Obstructive Pulmonary Disease (COPD). METHODS:We analyzed data obtained from two population-based surveys of adults (n = 2026) conducted in the same individuals 5-9 years (y) after their baseline examination in thr...
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doaj-f3aa0a57477140fc83850f430aa019dd2020-11-25T01:47:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01125e017703210.1371/journal.pone.0177032Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America.Rogelio Pérez-PadillaRosario Fernandez-PlataMaria Montes de OcaMaria Victorina Lopez-VarelaJose R JardimAdriana MuiñoGonzalo ValdiviaAna Maria B MenezesPLATINO groupBACKGROUND:Lung-function decline is one of the possible mechanisms leading to Chronic Obstructive Pulmonary Disease (COPD). METHODS:We analyzed data obtained from two population-based surveys of adults (n = 2026) conducted in the same individuals 5-9 years (y) after their baseline examination in three Latin-American cities. Post BronchoDilator (postBD) FEV1 decline in mL/y, as %predicted/y (%P/y) and % of baseline/y (%B/y) was calculated and the influence of age, gender, BMI, baseline lung function, BD response, exacerbations rate evaluated using multivariate models. RESULTS:Expressed in ml/y, the mean annual postBD FEV1 decline was 27 mL (0.22%P, 1.32%B) in patients with baseline COPD and 36 (0.14%P, 1.36%B) in those without. Faster decline (in mL/y) was associated with higher baseline lung function, with significant response to bronchodilators, older age and smoking at baseline, also in women with chronic cough and phlegm, or ≥2 respiratory exacerbations in the previous year, and in men with asthma. CONCLUSIONS:Lung function decline in a population-based cohort did not differ in obstructed and non-obstructed individuals, it was proportional to baseline FEV1, and was higher in smokers, elderly, and women with respiratory symptoms.http://europepmc.org/articles/PMC5417635?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rogelio Pérez-Padilla Rosario Fernandez-Plata Maria Montes de Oca Maria Victorina Lopez-Varela Jose R Jardim Adriana Muiño Gonzalo Valdivia Ana Maria B Menezes PLATINO group |
spellingShingle |
Rogelio Pérez-Padilla Rosario Fernandez-Plata Maria Montes de Oca Maria Victorina Lopez-Varela Jose R Jardim Adriana Muiño Gonzalo Valdivia Ana Maria B Menezes PLATINO group Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America. PLoS ONE |
author_facet |
Rogelio Pérez-Padilla Rosario Fernandez-Plata Maria Montes de Oca Maria Victorina Lopez-Varela Jose R Jardim Adriana Muiño Gonzalo Valdivia Ana Maria B Menezes PLATINO group |
author_sort |
Rogelio Pérez-Padilla |
title |
Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America. |
title_short |
Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America. |
title_full |
Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America. |
title_fullStr |
Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America. |
title_full_unstemmed |
Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America. |
title_sort |
lung function decline in subjects with and without copd in a population-based cohort in latin-america. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2017-01-01 |
description |
BACKGROUND:Lung-function decline is one of the possible mechanisms leading to Chronic Obstructive Pulmonary Disease (COPD). METHODS:We analyzed data obtained from two population-based surveys of adults (n = 2026) conducted in the same individuals 5-9 years (y) after their baseline examination in three Latin-American cities. Post BronchoDilator (postBD) FEV1 decline in mL/y, as %predicted/y (%P/y) and % of baseline/y (%B/y) was calculated and the influence of age, gender, BMI, baseline lung function, BD response, exacerbations rate evaluated using multivariate models. RESULTS:Expressed in ml/y, the mean annual postBD FEV1 decline was 27 mL (0.22%P, 1.32%B) in patients with baseline COPD and 36 (0.14%P, 1.36%B) in those without. Faster decline (in mL/y) was associated with higher baseline lung function, with significant response to bronchodilators, older age and smoking at baseline, also in women with chronic cough and phlegm, or ≥2 respiratory exacerbations in the previous year, and in men with asthma. CONCLUSIONS:Lung function decline in a population-based cohort did not differ in obstructed and non-obstructed individuals, it was proportional to baseline FEV1, and was higher in smokers, elderly, and women with respiratory symptoms. |
url |
http://europepmc.org/articles/PMC5417635?pdf=render |
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