Plant-Based Phytochemicals as Possible Alternative to Antibiotics in Combating Bacterial Drug Resistance
The unprecedented use of antibiotics that led to development of resistance affect human health worldwide. Prescription of antibiotics imprudently and irrationally in different diseases progressed with the acquisition and as such development of antibiotic resistant microbes that led to the resurgence...
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doaj-f3bf2d78785448699b1ae315aeb0f5e22020-11-25T03:51:45ZengMDPI AGAntibiotics2079-63822020-08-01948048010.3390/antibiotics9080480Plant-Based Phytochemicals as Possible Alternative to Antibiotics in Combating Bacterial Drug ResistanceHana Mohammed Al AlSheikh0Insha Sultan1Vijay Kumar2Irfan A. Rather3Hashem Al-Sheikh4Arif Tasleem Jan5Qazi Mohd Rizwanul Haq6Department of Prosthetic Dental Sciences, College of Dentistry, Kind Saud University, Riyadh, P.O.BOX 145111, Saudi ArabiaDepartment of Biosciences, Jamia Millia Islamia, New Delhi 110025, IndiaDepartment of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 38541, KoreaDepartment of Biological Sciences, Faculty of Science, King Abdul Aziz University, Jeddah, P.O. BOX 80200, Saudi ArabiaDepartment of Biological Sciences, College of Science, King Faisal University, Al-Ahsa 31982, Saudi ArabiaSchool of Biosciences and Biotechnology, Baba Ghulam Shah Badshah University, Rajouri 185234, IndiaDepartment of Biosciences, Jamia Millia Islamia, New Delhi 110025, IndiaThe unprecedented use of antibiotics that led to development of resistance affect human health worldwide. Prescription of antibiotics imprudently and irrationally in different diseases progressed with the acquisition and as such development of antibiotic resistant microbes that led to the resurgence of pathogenic strains harboring enhanced armors against existing therapeutics. Compromised the treatment regime of a broad range of antibiotics, rise in resistance has threatened human health and increased the treatment cost of diseases. Diverse on metabolic, genetic and physiological fronts, rapid progression of resistant microbes and the lack of a strategic management plan have led researchers to consider plant-derived substances (PDS) as alternative or in complementing antibiotics against the diseases. Considering the quantitative characteristics of plant constituents that attribute health beneficial effects, analytical procedures for their isolation, characterization and phytochemical testing for elucidating ethnopharmacological effects has being worked out for employment in the treatment of different diseases. With an immense potential to combat bacterial infections, PDSs such as polyphenols, alkaloids and tannins, present a great potential for use, either as antimicrobials or as antibiotic resistance modifiers. The present study focuses on the mechanisms by which PDSs help overcome the surge in resistance, approaches for screening different phytochemicals, methods employed in the identification of bioactive components and their testing and strategies that could be adopted for counteracting the lethal consequences of multidrug resistance.https://www.mdpi.com/2079-6382/9/8/480antibioticsbacteriahuman healthplant-derived substancesresistance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hana Mohammed Al AlSheikh Insha Sultan Vijay Kumar Irfan A. Rather Hashem Al-Sheikh Arif Tasleem Jan Qazi Mohd Rizwanul Haq |
spellingShingle |
Hana Mohammed Al AlSheikh Insha Sultan Vijay Kumar Irfan A. Rather Hashem Al-Sheikh Arif Tasleem Jan Qazi Mohd Rizwanul Haq Plant-Based Phytochemicals as Possible Alternative to Antibiotics in Combating Bacterial Drug Resistance Antibiotics antibiotics bacteria human health plant-derived substances resistance |
author_facet |
Hana Mohammed Al AlSheikh Insha Sultan Vijay Kumar Irfan A. Rather Hashem Al-Sheikh Arif Tasleem Jan Qazi Mohd Rizwanul Haq |
author_sort |
Hana Mohammed Al AlSheikh |
title |
Plant-Based Phytochemicals as Possible Alternative to Antibiotics in Combating Bacterial Drug Resistance |
title_short |
Plant-Based Phytochemicals as Possible Alternative to Antibiotics in Combating Bacterial Drug Resistance |
title_full |
Plant-Based Phytochemicals as Possible Alternative to Antibiotics in Combating Bacterial Drug Resistance |
title_fullStr |
Plant-Based Phytochemicals as Possible Alternative to Antibiotics in Combating Bacterial Drug Resistance |
title_full_unstemmed |
Plant-Based Phytochemicals as Possible Alternative to Antibiotics in Combating Bacterial Drug Resistance |
title_sort |
plant-based phytochemicals as possible alternative to antibiotics in combating bacterial drug resistance |
publisher |
MDPI AG |
series |
Antibiotics |
issn |
2079-6382 |
publishDate |
2020-08-01 |
description |
The unprecedented use of antibiotics that led to development of resistance affect human health worldwide. Prescription of antibiotics imprudently and irrationally in different diseases progressed with the acquisition and as such development of antibiotic resistant microbes that led to the resurgence of pathogenic strains harboring enhanced armors against existing therapeutics. Compromised the treatment regime of a broad range of antibiotics, rise in resistance has threatened human health and increased the treatment cost of diseases. Diverse on metabolic, genetic and physiological fronts, rapid progression of resistant microbes and the lack of a strategic management plan have led researchers to consider plant-derived substances (PDS) as alternative or in complementing antibiotics against the diseases. Considering the quantitative characteristics of plant constituents that attribute health beneficial effects, analytical procedures for their isolation, characterization and phytochemical testing for elucidating ethnopharmacological effects has being worked out for employment in the treatment of different diseases. With an immense potential to combat bacterial infections, PDSs such as polyphenols, alkaloids and tannins, present a great potential for use, either as antimicrobials or as antibiotic resistance modifiers. The present study focuses on the mechanisms by which PDSs help overcome the surge in resistance, approaches for screening different phytochemicals, methods employed in the identification of bioactive components and their testing and strategies that could be adopted for counteracting the lethal consequences of multidrug resistance. |
topic |
antibiotics bacteria human health plant-derived substances resistance |
url |
https://www.mdpi.com/2079-6382/9/8/480 |
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