The Effect of Iron Oxide Magnetic Nanoparticles on Smooth Muscle Cells
<p>Abstract</p> <p>Recently, magnetic nanoparticles of iron oxide (Fe<sub>3</sub>O<sub>4</sub>, γ-Fe<sub>2</sub>O<sub>3</sub>) have shown an increasing number of applications in the field of biomedicine, but some questions ha...
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doaj-f3c26609819f476abca3eba47b1e14d22020-11-24T23:29:57ZengSpringerOpenNanoscale Research Letters1931-75731556-276X2008-01-01417077The Effect of Iron Oxide Magnetic Nanoparticles on Smooth Muscle CellsChen XiangjianGu ChunrongXu JindanBian ZhipingYang DiZhang SongZhang YuGu Ning<p>Abstract</p> <p>Recently, magnetic nanoparticles of iron oxide (Fe<sub>3</sub>O<sub>4</sub>, γ-Fe<sub>2</sub>O<sub>3</sub>) have shown an increasing number of applications in the field of biomedicine, but some questions have been raised about the potential impact of these nanoparticles on the environment and human health. In this work, the three types of magnetic nanoparticles (DMSA-Fe<sub>2</sub>O<sub>3</sub>, APTS-Fe<sub>2</sub>O<sub>3</sub>, and GLU-Fe<sub>2</sub>O<sub>3</sub>) with the same crystal structure, magnetic properties, and size distribution was designed, prepared, and characterized by transmission electronic microscopy, powder X-ray diffraction, zeta potential analyzer, vibrating sample magnetometer, and Fourier transform Infrared spectroscopy. Then, we have investigated the effect of the three types of magnetic nanoparticles (DMSA-Fe<sub>2</sub>O<sub>3</sub>, APTS-Fe<sub>2</sub>O<sub>3</sub>, and GLU-Fe<sub>2</sub>O<sub>3</sub>) on smooth muscle cells (SMCs). Cellular uptake of nanoparticles by SMC displays the dose, the incubation time and surface property dependent patterns. Through the thin section TEM images, we observe that DMSA-Fe<sub>2</sub>O<sub>3</sub>is incorporated into the lysosome of SMCs. The magnetic nanoparticles have no inflammation impact, but decrease the viability of SMCs. The other questions about metabolism and other impacts will be the next subject of further studies.</p> http://dx.doi.org/10.1007/s11671-008-9204-7Magnetic nanoparticlesIron oxideSmooth muscle cellsCellular uptakeViability |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chen Xiangjian Gu Chunrong Xu Jindan Bian Zhiping Yang Di Zhang Song Zhang Yu Gu Ning |
spellingShingle |
Chen Xiangjian Gu Chunrong Xu Jindan Bian Zhiping Yang Di Zhang Song Zhang Yu Gu Ning The Effect of Iron Oxide Magnetic Nanoparticles on Smooth Muscle Cells Nanoscale Research Letters Magnetic nanoparticles Iron oxide Smooth muscle cells Cellular uptake Viability |
author_facet |
Chen Xiangjian Gu Chunrong Xu Jindan Bian Zhiping Yang Di Zhang Song Zhang Yu Gu Ning |
author_sort |
Chen Xiangjian |
title |
The Effect of Iron Oxide Magnetic Nanoparticles on Smooth Muscle Cells |
title_short |
The Effect of Iron Oxide Magnetic Nanoparticles on Smooth Muscle Cells |
title_full |
The Effect of Iron Oxide Magnetic Nanoparticles on Smooth Muscle Cells |
title_fullStr |
The Effect of Iron Oxide Magnetic Nanoparticles on Smooth Muscle Cells |
title_full_unstemmed |
The Effect of Iron Oxide Magnetic Nanoparticles on Smooth Muscle Cells |
title_sort |
effect of iron oxide magnetic nanoparticles on smooth muscle cells |
publisher |
SpringerOpen |
series |
Nanoscale Research Letters |
issn |
1931-7573 1556-276X |
publishDate |
2008-01-01 |
description |
<p>Abstract</p> <p>Recently, magnetic nanoparticles of iron oxide (Fe<sub>3</sub>O<sub>4</sub>, γ-Fe<sub>2</sub>O<sub>3</sub>) have shown an increasing number of applications in the field of biomedicine, but some questions have been raised about the potential impact of these nanoparticles on the environment and human health. In this work, the three types of magnetic nanoparticles (DMSA-Fe<sub>2</sub>O<sub>3</sub>, APTS-Fe<sub>2</sub>O<sub>3</sub>, and GLU-Fe<sub>2</sub>O<sub>3</sub>) with the same crystal structure, magnetic properties, and size distribution was designed, prepared, and characterized by transmission electronic microscopy, powder X-ray diffraction, zeta potential analyzer, vibrating sample magnetometer, and Fourier transform Infrared spectroscopy. Then, we have investigated the effect of the three types of magnetic nanoparticles (DMSA-Fe<sub>2</sub>O<sub>3</sub>, APTS-Fe<sub>2</sub>O<sub>3</sub>, and GLU-Fe<sub>2</sub>O<sub>3</sub>) on smooth muscle cells (SMCs). Cellular uptake of nanoparticles by SMC displays the dose, the incubation time and surface property dependent patterns. Through the thin section TEM images, we observe that DMSA-Fe<sub>2</sub>O<sub>3</sub>is incorporated into the lysosome of SMCs. The magnetic nanoparticles have no inflammation impact, but decrease the viability of SMCs. The other questions about metabolism and other impacts will be the next subject of further studies.</p> |
topic |
Magnetic nanoparticles Iron oxide Smooth muscle cells Cellular uptake Viability |
url |
http://dx.doi.org/10.1007/s11671-008-9204-7 |
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