Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG

Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG

Summary: Diffuse intrinsic pontine glioma (DIPG) is an aggressive and incurable childhood brain tumor for which new treatments are needed. CBL0137 is an anti-cancer compound developed from quinacrine that targets facilitates chromatin transcription (FACT), a chromatin remodeling complex involved in...

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Bibliographic Details
Main Authors: Anahid Ehteda, Sandy Simon, Laura Franshaw, Federico M. Giorgi, Jie Liu, Swapna Joshi, Jourdin R.C. Rouaen, Chi Nam Ignatius Pang, Ruby Pandher, Chelsea Mayoh, Yujie Tang, Aaminah Khan, Caitlin Ung, Ornella Tolhurst, Anne Kankean, Elisha Hayden, Rebecca Lehmann, Sylvie Shen, Anjana Gopalakrishnan, Peter Trebilcock, Katerina Gurova, Andrei V. Gudkov, Murray D. Norris, Michelle Haber, Orazio Vittorio, Maria Tsoli, David S. Ziegler
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
DIPG
brainstem glioma
H3K27M
facilitates chromatin transcription complex
HDAC
EZH2
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721003089

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