Hypotensive Activity of Ethanolic Extracts of L. Leaves and Fruit in Dexamethasone-Induced Hypertensive Rat

• Main Authors: Dyan Wigati BSc, MSc, Khoerul Anwar BSc, MSc, Sudarsono BSc, PhD, Agung Endro Nugroho BSc, MSc, PhD
• Format: Article
• Language: English
• Published: SAGE Publishing 2017-01-01
• Series: Journal of Evidence-Based Complementary & Alternative Medicine
• Online Access: https://doi.org/10.1177/2156587216653660

The effect of ethanolic extract of Morinda citrifolia leaves and fruit on blood pressure in dexamethasone-induced hypertension rat was evaluated. Total phenolic content of Morinda citrifolia leaves ethanolic extract (MCLEE) and Morinda citrifolia leaves ethanolic extract (MCFEE) was 1.789 ± 0.116 and 1.677 ± 0.051 mg of gallic acid equivalents per gram sample, respectively. Rutin level in MCLEE was 0.92 ± 0.19%, and scopoletin level in MCFEE was 0.46 ± 0.05%. MCLEE, MCFEE, and its extract combination significantly decreased the blood pressure of hypertensive rats. The combination group showed highest hypotensive activity by lowering systolic blood pressure by 16.71 ± 3.95%, diastolic blood pressure by 21.49 ± 7.90%, and mean arterial blood pressure by 19.58% ± 6.35. All extract treatments have not been able to repair or inhibit renal damage caused by dexamethasone induction.