Hormonal profile in children with enteroviral meningitis
Participation of hormones in maintaining immune homeostasis is a complicated process as the hormones can have both immunomodulatory and immunosuppressive effect. Changes in the hypothalamic-pituitary-thyroid axis in diseases may appear low triiodothyronine, and is currently being discussed the issue...
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Journal Infectology
2016-11-01
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doaj-f3d491a659a44b2287f8a580c0a742872021-08-02T08:43:21ZrusJournal InfectologyŽurnal Infektologii 2072-67322016-11-01835965494Hormonal profile in children with enteroviral meningitisA. U. Sabitov0Yu. B. Khamanova1O. A. Chesnakova2A. O. Ovchinnikova3S. V. Belyaeva4Ural State Medical University, Ekaterinburg, RussiaUral State Medical University, Ekaterinburg, RussiaUral State Medical University, Ekaterinburg, RussiaCity Clinical Hospital № 40, Ekaterinburg, RussiaClinical and Diagnostic Center, Ekaterinburg, RussiaParticipation of hormones in maintaining immune homeostasis is a complicated process as the hormones can have both immunomodulatory and immunosuppressive effect. Changes in the hypothalamic-pituitary-thyroid axis in diseases may appear low triiodothyronine, and is currently being discussed the issue of the state of development, characterized by a decrease in blood levels of thyroid hormone in the absence of pathology of the thyroid gland. In the literature there is the term - (nonthyroidal illness syndrome) «netireoidnyh disease syndrome.» One of the most debated issues related to the pathogenesis of diseases netireoidnyh syndrome - this is the role of proinflammatory cytokines in violation of the secretory activity of the thyroid gland and the hypothalamus-pituitary-thyroid axis in general. However, the exact mechanisms for reducing serum triiodothyronine remain poorly studied, including thyroid status and relationship with objective criteria systemic inflammation in children, especially during viral infection. The paper presents the materials and the results of an open prospective study conducted in the city of Yekaterinburg in 2009-2012. We observed 71 children with enteroviral meningitis at the age of three to fourteen. We studied the levels of thyroid-stimulating hormone, triiodothyronine, thyroxine and intracellular cytokine synthesis in blood lymphocytes. The nature of changes in hormonal status in children with enteroviral meningitis can be treated as a syndrome netireoidnyh diseases. Low level of triiodothyronine correlates with the time of CSF readjustment and control pleocytosis indicators, more long-term liquor rehabilitation is mentioned in children with low initial level of triiodothyronine, the odds ratio (OR = 7,3, 95% CI 0,9: 6,7). This syndrome is secondary and occurs as the result of cytokine system on the thyroid gland exposure.https://journal.niidi.ru/jofin/article/view/506childrenenterovirus infectionmeningitistriiodothyronine. |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
A. U. Sabitov Yu. B. Khamanova O. A. Chesnakova A. O. Ovchinnikova S. V. Belyaeva |
spellingShingle |
A. U. Sabitov Yu. B. Khamanova O. A. Chesnakova A. O. Ovchinnikova S. V. Belyaeva Hormonal profile in children with enteroviral meningitis Žurnal Infektologii children enterovirus infection meningitis triiodothyronine. |
author_facet |
A. U. Sabitov Yu. B. Khamanova O. A. Chesnakova A. O. Ovchinnikova S. V. Belyaeva |
author_sort |
A. U. Sabitov |
title |
Hormonal profile in children with enteroviral meningitis |
title_short |
Hormonal profile in children with enteroviral meningitis |
title_full |
Hormonal profile in children with enteroviral meningitis |
title_fullStr |
Hormonal profile in children with enteroviral meningitis |
title_full_unstemmed |
Hormonal profile in children with enteroviral meningitis |
title_sort |
hormonal profile in children with enteroviral meningitis |
publisher |
Journal Infectology |
series |
Žurnal Infektologii |
issn |
2072-6732 |
publishDate |
2016-11-01 |
description |
Participation of hormones in maintaining immune homeostasis is a complicated process as the hormones can have both immunomodulatory and immunosuppressive effect. Changes in the hypothalamic-pituitary-thyroid axis in diseases may appear low triiodothyronine, and is currently being discussed the issue of the state of development, characterized by a decrease in blood levels of thyroid hormone in the absence of pathology of the thyroid gland. In the literature there is the term - (nonthyroidal illness syndrome) «netireoidnyh disease syndrome.» One of the most debated issues related to the pathogenesis of diseases netireoidnyh syndrome - this is the role of proinflammatory cytokines in violation of the secretory activity of the thyroid gland and the hypothalamus-pituitary-thyroid axis in general. However, the exact mechanisms for reducing serum triiodothyronine remain poorly studied, including thyroid status and relationship with objective criteria systemic inflammation in children, especially during viral infection. The paper presents the materials and the results of an open prospective study conducted in the city of Yekaterinburg in 2009-2012. We observed 71 children with enteroviral meningitis at the age of three to fourteen. We studied the levels of thyroid-stimulating hormone, triiodothyronine, thyroxine and intracellular cytokine synthesis in blood lymphocytes. The nature of changes in hormonal status in children with enteroviral meningitis can be treated as a syndrome netireoidnyh diseases. Low level of triiodothyronine correlates with the time of CSF readjustment and control pleocytosis indicators, more long-term liquor rehabilitation is mentioned in children with low initial level of triiodothyronine, the odds ratio (OR = 7,3, 95% CI 0,9: 6,7). This syndrome is secondary and occurs as the result of cytokine system on the thyroid gland exposure. |
topic |
children enterovirus infection meningitis triiodothyronine. |
url |
https://journal.niidi.ru/jofin/article/view/506 |
work_keys_str_mv |
AT ausabitov hormonalprofileinchildrenwithenteroviralmeningitis AT yubkhamanova hormonalprofileinchildrenwithenteroviralmeningitis AT oachesnakova hormonalprofileinchildrenwithenteroviralmeningitis AT aoovchinnikova hormonalprofileinchildrenwithenteroviralmeningitis AT svbelyaeva hormonalprofileinchildrenwithenteroviralmeningitis |
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