Sectoral activation of glia in an inducible mouse model of autosomal dominant retinitis pigmentosa

Abstract Retinitis pigmentosa (RP) is a group of blinding disorders caused by diverse mutations, including in rhodopsin (RHO). Effective therapies have yet to be discovered. The I307N Rho mouse is a light-inducible model of autosomal dominant RP. Our purpose was to describe the glial response in thi...

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Bibliographic Details
Main Authors: Michael T. Massengill, Neil F. Ash, Brianna M. Young, Cristhian J. Ildefonso, Alfred S. Lewin
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-73749-y