Cell Intrinsic Roles of Apoptosis-Associated Speck-Like Protein in Regulating Innate and Adaptive Immune Responses

Cell Intrinsic Roles of Apoptosis-Associated Speck-Like Protein in Regulating Innate and Adaptive Immune Responses

The role of apoptosis-associated speck-Like protein (ASC) in the assembly of the inflammasome complex within macrophages has been elucidated in several studies. In this particular role, ASC functions as an adaptor protein by linking nod-like receptors (NLRs) and procaspase-1, thereby leading to the...

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Main Authors: Hoda Hassan, Amal O. Amer
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1100/2011/429192
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spelling doaj-f3e4b68e6b8840ebbb6480c6f91db5f72020-11-24T22:15:14ZengHindawi LimitedThe Scientific World Journal1537-744X2011-01-01112418242310.1100/2011/429192429192Cell Intrinsic Roles of Apoptosis-Associated Speck-Like Protein in Regulating Innate and Adaptive Immune ResponsesHoda Hassan0Amal O. Amer1Department of Microbial Infection and Immunity, Center for Microbial Interface Biology, and Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USADepartment of Microbial Infection and Immunity, Center for Microbial Interface Biology, and Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USAThe role of apoptosis-associated speck-Like protein (ASC) in the assembly of the inflammasome complex within macrophages has been elucidated in several studies. In this particular role, ASC functions as an adaptor protein by linking nod-like receptors (NLRs) and procaspase-1, thereby leading to the activation of caspase-1 to cleave inflammatory cytokines IL-1β and IL-18 and inducing pyroptosis. It has been noted that ASC maintains inflammasome-independent roles, including but not limited to controlling the expression of Dock2 and mitogen-activated protein kinases (MAPK/ERK2) and regulating the NF-κB pathway. This paper will emphasize the major roles of ASC during pathogen infection, the mechanisms by which it mediates inflammation, and discuss its more recently discovered functions.http://dx.doi.org/10.1100/2011/429192
collection DOAJ
language English
format Article
sources DOAJ
author Hoda Hassan
Amal O. Amer
spellingShingle Hoda Hassan
Amal O. Amer
Cell Intrinsic Roles of Apoptosis-Associated Speck-Like Protein in Regulating Innate and Adaptive Immune Responses
The Scientific World Journal
author_facet Hoda Hassan
Amal O. Amer
author_sort Hoda Hassan
title Cell Intrinsic Roles of Apoptosis-Associated Speck-Like Protein in Regulating Innate and Adaptive Immune Responses
title_short Cell Intrinsic Roles of Apoptosis-Associated Speck-Like Protein in Regulating Innate and Adaptive Immune Responses
title_full Cell Intrinsic Roles of Apoptosis-Associated Speck-Like Protein in Regulating Innate and Adaptive Immune Responses
title_fullStr Cell Intrinsic Roles of Apoptosis-Associated Speck-Like Protein in Regulating Innate and Adaptive Immune Responses
title_full_unstemmed Cell Intrinsic Roles of Apoptosis-Associated Speck-Like Protein in Regulating Innate and Adaptive Immune Responses
title_sort cell intrinsic roles of apoptosis-associated speck-like protein in regulating innate and adaptive immune responses
publisher Hindawi Limited
series The Scientific World Journal
issn 1537-744X
publishDate 2011-01-01
description The role of apoptosis-associated speck-Like protein (ASC) in the assembly of the inflammasome complex within macrophages has been elucidated in several studies. In this particular role, ASC functions as an adaptor protein by linking nod-like receptors (NLRs) and procaspase-1, thereby leading to the activation of caspase-1 to cleave inflammatory cytokines IL-1β and IL-18 and inducing pyroptosis. It has been noted that ASC maintains inflammasome-independent roles, including but not limited to controlling the expression of Dock2 and mitogen-activated protein kinases (MAPK/ERK2) and regulating the NF-κB pathway. This paper will emphasize the major roles of ASC during pathogen infection, the mechanisms by which it mediates inflammation, and discuss its more recently discovered functions.
url http://dx.doi.org/10.1100/2011/429192
work_keys_str_mv AT hodahassan cellintrinsicrolesofapoptosisassociatedspecklikeproteininregulatinginnateandadaptiveimmuneresponses
AT amaloamer cellintrinsicrolesofapoptosisassociatedspecklikeproteininregulatinginnateandadaptiveimmuneresponses
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