Prevalence of human papillomavirus and its prognostic value in vulvar cancer: A systematic review and meta-analysis.
The purpose of this study was to estimate the prevalence of human papillomavirus (HPV) in vulvar cancer and determine whether positive HPV in vulvar cancer was associated with a better prognosis. Literature searches of Ovid EMBASE, PubMed, Web of Science and Cochrane Library were performed to identi...
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doaj-f3ea3607bd324be18b711830e079c7162020-11-25T01:25:28ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01139e020416210.1371/journal.pone.0204162Prevalence of human papillomavirus and its prognostic value in vulvar cancer: A systematic review and meta-analysis.Jianxin ZhangYang ZhangZhenyu ZhangThe purpose of this study was to estimate the prevalence of human papillomavirus (HPV) in vulvar cancer and determine whether positive HPV in vulvar cancer was associated with a better prognosis. Literature searches of Ovid EMBASE, PubMed, Web of Science and Cochrane Library were performed to identify related studies published from January 2000 to May 2017. A total of 33 studies including 7,721 subjects were selected in this meta-analysis. Overall, the HPV prevalence in vulvar cancer tissue was 34% (95% CI: 28%-39%) with 45% (95% CI: 28%-64%) in Asian populations and 34% (95% CI: 26%-42%) in Caucasian populations. The HPV-positive vulvar cancer was associated with better overall survival (hazard ratio = 0.64, 95% CI: 0.47-0.87; P = 0.004) and recurrence-free survival (hazard ratio = 0.66, 95% CI: 0.45-0.97; P = 0.03) compared with HPV-negative counterpart. HPV status may play an important role in predicting the prognosis of patients with vulvar cancer. The HPV-positive vulvar cancer women might relatively have a better survival than HPV-negative ones.http://europepmc.org/articles/PMC6157864?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jianxin Zhang Yang Zhang Zhenyu Zhang |
spellingShingle |
Jianxin Zhang Yang Zhang Zhenyu Zhang Prevalence of human papillomavirus and its prognostic value in vulvar cancer: A systematic review and meta-analysis. PLoS ONE |
author_facet |
Jianxin Zhang Yang Zhang Zhenyu Zhang |
author_sort |
Jianxin Zhang |
title |
Prevalence of human papillomavirus and its prognostic value in vulvar cancer: A systematic review and meta-analysis. |
title_short |
Prevalence of human papillomavirus and its prognostic value in vulvar cancer: A systematic review and meta-analysis. |
title_full |
Prevalence of human papillomavirus and its prognostic value in vulvar cancer: A systematic review and meta-analysis. |
title_fullStr |
Prevalence of human papillomavirus and its prognostic value in vulvar cancer: A systematic review and meta-analysis. |
title_full_unstemmed |
Prevalence of human papillomavirus and its prognostic value in vulvar cancer: A systematic review and meta-analysis. |
title_sort |
prevalence of human papillomavirus and its prognostic value in vulvar cancer: a systematic review and meta-analysis. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2018-01-01 |
description |
The purpose of this study was to estimate the prevalence of human papillomavirus (HPV) in vulvar cancer and determine whether positive HPV in vulvar cancer was associated with a better prognosis. Literature searches of Ovid EMBASE, PubMed, Web of Science and Cochrane Library were performed to identify related studies published from January 2000 to May 2017. A total of 33 studies including 7,721 subjects were selected in this meta-analysis. Overall, the HPV prevalence in vulvar cancer tissue was 34% (95% CI: 28%-39%) with 45% (95% CI: 28%-64%) in Asian populations and 34% (95% CI: 26%-42%) in Caucasian populations. The HPV-positive vulvar cancer was associated with better overall survival (hazard ratio = 0.64, 95% CI: 0.47-0.87; P = 0.004) and recurrence-free survival (hazard ratio = 0.66, 95% CI: 0.45-0.97; P = 0.03) compared with HPV-negative counterpart. HPV status may play an important role in predicting the prognosis of patients with vulvar cancer. The HPV-positive vulvar cancer women might relatively have a better survival than HPV-negative ones. |
url |
http://europepmc.org/articles/PMC6157864?pdf=render |
work_keys_str_mv |
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