Role of miRNA Let-7 and Its Major Targets in Prostate Cancer
Prostate cancer is worldwide the sixth leading cause of cancer related death in men thus early detection and successful treatment are still of major interest. The commonly performed screening of the prostate-specific antigen (PSA) is controversially discussed, as in many patients the prostate-specif...
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Online Access: | http://dx.doi.org/10.1155/2014/376326 |
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doaj-f3ebdb7743b34c75a7e0578d91e4b0ad2020-11-24T21:46:33ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/376326376326Role of miRNA Let-7 and Its Major Targets in Prostate CancerSiegfried Wagner0Anaclet Ngezahayo1Hugo Murua Escobar2Ingo Nolte3Small Animal Clinic, University of Veterinary Medicine Hannover, 30559 Hannover, GermanyInstitute of Biophysics, University Hannover, 30419 Hannover, GermanySmall Animal Clinic, University of Veterinary Medicine Hannover, 30559 Hannover, GermanySmall Animal Clinic, University of Veterinary Medicine Hannover, 30559 Hannover, GermanyProstate cancer is worldwide the sixth leading cause of cancer related death in men thus early detection and successful treatment are still of major interest. The commonly performed screening of the prostate-specific antigen (PSA) is controversially discussed, as in many patients the prostate-specific antigen levels are chronically elevated in the absence of cancer. Due to the unsatisfying efficiency of available prostate cancer screening markers and the current treatment outcome of the aggressive hormone refractory prostate cancer, the evaluation of novel molecular markers and targets is considered an issue of high importance. MicroRNAs are relatively stable in body fluids orchestrating simultaneously the expression of many genes. These molecules are currently discussed to bear a greater diagnostic potential than protein-coding genes, being additionally promising therapeutic drugs and/or targets. Herein we review the potential impact of the microRNA let-7 family on prostate cancer and show how deregulation of several of its target genes could influence the cellular equilibrium in the prostate gland, promoting cancer development as they do in a variety of other human malignant neoplasias.http://dx.doi.org/10.1155/2014/376326 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Siegfried Wagner Anaclet Ngezahayo Hugo Murua Escobar Ingo Nolte |
spellingShingle |
Siegfried Wagner Anaclet Ngezahayo Hugo Murua Escobar Ingo Nolte Role of miRNA Let-7 and Its Major Targets in Prostate Cancer BioMed Research International |
author_facet |
Siegfried Wagner Anaclet Ngezahayo Hugo Murua Escobar Ingo Nolte |
author_sort |
Siegfried Wagner |
title |
Role of miRNA Let-7 and Its Major Targets in Prostate Cancer |
title_short |
Role of miRNA Let-7 and Its Major Targets in Prostate Cancer |
title_full |
Role of miRNA Let-7 and Its Major Targets in Prostate Cancer |
title_fullStr |
Role of miRNA Let-7 and Its Major Targets in Prostate Cancer |
title_full_unstemmed |
Role of miRNA Let-7 and Its Major Targets in Prostate Cancer |
title_sort |
role of mirna let-7 and its major targets in prostate cancer |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2014-01-01 |
description |
Prostate cancer is worldwide the sixth leading cause of cancer related death in men thus early detection and successful treatment are still of major interest. The commonly performed screening of the prostate-specific antigen (PSA) is controversially discussed, as in many patients the prostate-specific antigen levels are chronically elevated in the absence of cancer. Due to the unsatisfying efficiency of available prostate cancer screening markers and the current treatment outcome of the aggressive hormone refractory prostate cancer, the evaluation of novel molecular markers and targets is considered an issue of high importance. MicroRNAs are relatively stable in body fluids orchestrating simultaneously the expression of many genes. These molecules are currently discussed to bear a greater diagnostic potential than protein-coding genes, being additionally promising therapeutic drugs and/or targets. Herein we review the potential impact of the microRNA let-7 family on prostate cancer and show how deregulation of several of its target genes could influence the cellular equilibrium in the prostate gland, promoting cancer development as they do in a variety of other human malignant neoplasias. |
url |
http://dx.doi.org/10.1155/2014/376326 |
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