Imbalance Between Interleukin-1β and Interleukin-1 Receptor Antagonist in Epicardial Adipose Tissue Is Associated With Non ST-Segment Elevation Acute Coronary Syndrome

Imbalance Between Interleukin-1β and Interleukin-1 Receptor Antagonist in Epicardial Adipose Tissue Is Associated With Non ST-Segment Elevation Acute Coronary Syndrome

IntroductionInterleukin-1beta (IL-1β) is crucially involved in the pathogenesis of coronary atherosclerotic diseases (CAD) and its inhibition has proven cardiovascular benefits. Epicardial adipose tissue (EAT) is a local source of inflammatory mediators which may negatively affect the surrounding co...

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Main Authors: Valentina Parisi, Laura Petraglia, Serena Cabaro, Vittoria D’Esposito, Dario Bruzzese, Giusy Ferraro, Andrea Urbani, Fabrizio Vincenzo Grieco, Maddalena Conte, Aurelio Caruso, Maria Gabriella Grimaldi, Antonio de Bellis, Salvatore Severino, Pasquale Campana, Emanuele Pilato, Giuseppe Comentale, Maddalena Raia, Giulia Scalia, Giuseppe Castaldo, Pietro Formisano, Dario Leosco
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Physiology
Subjects:
epicardial adipose tissue
inflammation
IL-1
IL1-ra
acute coronary syndrome
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00042/full

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