Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss

RANKL is a cytokine produced as a membrane-bound and a secreted protein. Here, using mice lacking soluble RANKL, the authors show that the secreted protein is important for osteoclast function, but not for mammary gland and lymphocyte development.

Bibliographic Details
Main Authors:	Jinhu Xiong, Keisha Cawley, Marilina Piemontese, Yuko Fujiwara, Haibo Zhao, Joseph J. Goellner, Charles A. O’Brien
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-05244-y

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spelling	doaj-f3fdb2bc80d5499aa847b891e2ea7b502021-05-11T10:20:09ZengNature Publishing GroupNature Communications2041-17232018-07-01911710.1038/s41467-018-05244-ySoluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone lossJinhu Xiong0Keisha Cawley1Marilina Piemontese2Yuko Fujiwara3Haibo Zhao4Joseph J. Goellner5Charles A. O’Brien6Center for Musculoskeletal Disease Research, University of Arkansas for Medical SciencesCenter for Musculoskeletal Disease Research, University of Arkansas for Medical SciencesDivision of Endocrinology, University of Arkansas for Medical SciencesDivision of Endocrinology, University of Arkansas for Medical SciencesDivision of Endocrinology, University of Arkansas for Medical SciencesCenter for Musculoskeletal Disease Research, University of Arkansas for Medical SciencesCenter for Musculoskeletal Disease Research, University of Arkansas for Medical SciencesRANKL is a cytokine produced as a membrane-bound and a secreted protein. Here, using mice lacking soluble RANKL, the authors show that the secreted protein is important for osteoclast function, but not for mammary gland and lymphocyte development.https://doi.org/10.1038/s41467-018-05244-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jinhu Xiong Keisha Cawley Marilina Piemontese Yuko Fujiwara Haibo Zhao Joseph J. Goellner Charles A. O’Brien
spellingShingle	Jinhu Xiong Keisha Cawley Marilina Piemontese Yuko Fujiwara Haibo Zhao Joseph J. Goellner Charles A. O’Brien Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss Nature Communications
author_facet	Jinhu Xiong Keisha Cawley Marilina Piemontese Yuko Fujiwara Haibo Zhao Joseph J. Goellner Charles A. O’Brien
author_sort	Jinhu Xiong
title	Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss
title_short	Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss
title_full	Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss
title_fullStr	Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss
title_full_unstemmed	Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss
title_sort	soluble rankl contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-07-01
description	RANKL is a cytokine produced as a membrane-bound and a secreted protein. Here, using mice lacking soluble RANKL, the authors show that the secreted protein is important for osteoclast function, but not for mammary gland and lymphocyte development.
url	https://doi.org/10.1038/s41467-018-05244-y
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Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss

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