Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss
RANKL is a cytokine produced as a membrane-bound and a secreted protein. Here, using mice lacking soluble RANKL, the authors show that the secreted protein is important for osteoclast function, but not for mammary gland and lymphocyte development.
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-07-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-05244-y |