Impact of kinase activating and inactivating patient mutations on binary PKA interactions

Impact of kinase activating and inactivating patient mutations on binary PKA interactions

The second messenger molecule cAMP links extracellular signals to intracellular responses. The main cellular cAMP effector is the compartmentalized protein kinase A (PKA). Upon receptor initiated cAMP-mobilization, PKA regulatory subunits (R) bind cAMP thereby triggering dissociation and activation...

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Bibliographic Details
Main Authors: Ruth eRöck, Johanna Elisabeth Mayrhofer, Verena eBachmann, Eduard eStefan
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Pharmacology
Subjects:
Carney Complex
GPCR
molecular interactions
Acrodysostosis
Protein-fragment complementation assay
patient mutations
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00170/full

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