Glutamine and Alanyl-Glutamine Increase RhoA Expression and Reduce Clostridium difficile Toxin-A-Induced Intestinal Epithelial Cell Damage

Glutamine and Alanyl-Glutamine Increase RhoA Expression and Reduce Clostridium difficile Toxin-A-Induced Intestinal Epithelial Cell Damage

Clostridium difficile is a major cause of antibiotic-associated colitis and is associated with significant morbidity and mortality. Glutamine (Gln) is a major fuel for the intestinal cell population. Alanyl-glutamine (Ala-Gln) is a dipeptide that is highly soluble and well tolerated. IEC-6 cells wer...

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Bibliographic Details
Main Authors: Ana A. Q. A. Santos, Manuel B. Braga-Neto, Marcelo R. Oliveira, Rosemeire S. Freire, Eduardo B. Barros, Thiago M. Santiago, Luciana M. Rebelo, Claudia Mermelstein, Cirle A. Warren, Richard L. Guerrant, Gerly A. C. Brito
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2013/152052

Internet

http://dx.doi.org/10.1155/2013/152052

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