Origin of the Autophagosome Membrane in Mammals

Origin of the Autophagosome Membrane in Mammals

Autophagy begins with the nucleation of phagophores, which then expand to give rise to the double-membrane autophagosomes. Autophagosomes ultimately fuse with lysosomes, where the cytosolic cargoes are degraded. Accumulation of autophagosomes is a hallmark of autophagy and neurodegenerative disorder...

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Main Authors: Yun Wei, Meixia Liu, Xianxiao Li, Jiangang Liu, Hao Li
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2018/1012789
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spelling doaj-f407aba3628d4daa86bd65e5f9a854ee2020-11-24T21:07:58ZengHindawi LimitedBioMed Research International2314-61332314-61412018-01-01201810.1155/2018/10127891012789Origin of the Autophagosome Membrane in MammalsYun Wei0Meixia Liu1Xianxiao Li2Jiangang Liu3Hao Li4Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, ChinaXiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, ChinaDepartment of Oncology, Air Force General Hospital, Beijing 100142, ChinaXiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, ChinaXiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, ChinaAutophagy begins with the nucleation of phagophores, which then expand to give rise to the double-membrane autophagosomes. Autophagosomes ultimately fuse with lysosomes, where the cytosolic cargoes are degraded. Accumulation of autophagosomes is a hallmark of autophagy and neurodegenerative disorders including Alzheimer’s and Huntington’s disease. In recent years, the sources of autophagosome membrane have attracted a great deal of interests, even so, the membrane donors for autophagosomes are still under debate. In this review, we describe the probable sources of autophagosome membrane.http://dx.doi.org/10.1155/2018/1012789
collection DOAJ
language English
format Article
sources DOAJ
author Yun Wei
Meixia Liu
Xianxiao Li
Jiangang Liu
Hao Li
spellingShingle Yun Wei
Meixia Liu
Xianxiao Li
Jiangang Liu
Hao Li
Origin of the Autophagosome Membrane in Mammals
BioMed Research International
author_facet Yun Wei
Meixia Liu
Xianxiao Li
Jiangang Liu
Hao Li
author_sort Yun Wei
title Origin of the Autophagosome Membrane in Mammals
title_short Origin of the Autophagosome Membrane in Mammals
title_full Origin of the Autophagosome Membrane in Mammals
title_fullStr Origin of the Autophagosome Membrane in Mammals
title_full_unstemmed Origin of the Autophagosome Membrane in Mammals
title_sort origin of the autophagosome membrane in mammals
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2018-01-01
description Autophagy begins with the nucleation of phagophores, which then expand to give rise to the double-membrane autophagosomes. Autophagosomes ultimately fuse with lysosomes, where the cytosolic cargoes are degraded. Accumulation of autophagosomes is a hallmark of autophagy and neurodegenerative disorders including Alzheimer’s and Huntington’s disease. In recent years, the sources of autophagosome membrane have attracted a great deal of interests, even so, the membrane donors for autophagosomes are still under debate. In this review, we describe the probable sources of autophagosome membrane.
url http://dx.doi.org/10.1155/2018/1012789
work_keys_str_mv AT yunwei originoftheautophagosomemembraneinmammals
AT meixialiu originoftheautophagosomemembraneinmammals
AT xianxiaoli originoftheautophagosomemembraneinmammals
AT jiangangliu originoftheautophagosomemembraneinmammals
AT haoli originoftheautophagosomemembraneinmammals
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