Cannabidiol and the Remainder of the Plant Extract Modulate the Effects of Δ9-Tetrahydrocannabinol on Fear Memory Reconsolidation

Cannabidiol and the Remainder of the Plant Extract Modulate the Effects of Δ9-Tetrahydrocannabinol on Fear Memory Reconsolidation

Background: Δ9-Tetrahydrocannabinol (THC, a CB1 receptor agonist) and Cannabidiol (CBD, a non-competitive antagonist of endogenous CB1 and CB2 ligands) are two primary components of Cannabis species, and may modulate fear learning in mammals. The CB1 receptor is widely distributed throughout the cor...

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Bibliographic Details
Main Authors: Anthony Murkar, Pam Kent, Christian Cayer, Jon James, Tony Durst, Zul Merali
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
reconsolidation
blockade
fear
memory
cannabinoids
cannabis
Online Access:https://www.frontiersin.org/article/10.3389/fnbeh.2019.00174/full

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