White Matter Microstructural Damage as an Early Sign of Subjective Cognitive Decline
Background and Objective: Subjective cognitive decline (SCD) is considered a preclinical state of Alzheimer’s disease (AD) and may represent a more advanced preclinical status than amnestic mild cognitive impairment (aMCI). Our aim was to explore changes in the white matter (WM) microstructure and t...
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Frontiers Media S.A.
2020-01-01
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Series: | Frontiers in Aging Neuroscience |
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Online Access: | https://www.frontiersin.org/article/10.3389/fnagi.2019.00378/full |
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English |
format |
Article |
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DOAJ |
author |
Caimei Luo Caimei Luo Caimei Luo Caimei Luo Mengchun Li Mengchun Li Mengchun Li Mengchun Li Ruomeng Qin Ruomeng Qin Ruomeng Qin Ruomeng Qin Haifeng Chen Haifeng Chen Haifeng Chen Haifeng Chen Dan Yang Dan Yang Dan Yang Dan Yang Lili Huang Lili Huang Lili Huang Lili Huang Renyuan Liu Renyuan Liu Renyuan Liu Renyuan Liu Yun Xu Yun Xu Yun Xu Yun Xu Feng Bai Feng Bai Feng Bai Feng Bai Hui Zhao Hui Zhao Hui Zhao Hui Zhao |
spellingShingle |
Caimei Luo Caimei Luo Caimei Luo Caimei Luo Mengchun Li Mengchun Li Mengchun Li Mengchun Li Ruomeng Qin Ruomeng Qin Ruomeng Qin Ruomeng Qin Haifeng Chen Haifeng Chen Haifeng Chen Haifeng Chen Dan Yang Dan Yang Dan Yang Dan Yang Lili Huang Lili Huang Lili Huang Lili Huang Renyuan Liu Renyuan Liu Renyuan Liu Renyuan Liu Yun Xu Yun Xu Yun Xu Yun Xu Feng Bai Feng Bai Feng Bai Feng Bai Hui Zhao Hui Zhao Hui Zhao Hui Zhao White Matter Microstructural Damage as an Early Sign of Subjective Cognitive Decline Frontiers in Aging Neuroscience Alzheimer’s disease subjective cognitive decline amnestic mild cognitive impairment diffusion tensor imaging white matter pathway |
author_facet |
Caimei Luo Caimei Luo Caimei Luo Caimei Luo Mengchun Li Mengchun Li Mengchun Li Mengchun Li Ruomeng Qin Ruomeng Qin Ruomeng Qin Ruomeng Qin Haifeng Chen Haifeng Chen Haifeng Chen Haifeng Chen Dan Yang Dan Yang Dan Yang Dan Yang Lili Huang Lili Huang Lili Huang Lili Huang Renyuan Liu Renyuan Liu Renyuan Liu Renyuan Liu Yun Xu Yun Xu Yun Xu Yun Xu Feng Bai Feng Bai Feng Bai Feng Bai Hui Zhao Hui Zhao Hui Zhao Hui Zhao |
author_sort |
Caimei Luo |
title |
White Matter Microstructural Damage as an Early Sign of Subjective Cognitive Decline |
title_short |
White Matter Microstructural Damage as an Early Sign of Subjective Cognitive Decline |
title_full |
White Matter Microstructural Damage as an Early Sign of Subjective Cognitive Decline |
title_fullStr |
White Matter Microstructural Damage as an Early Sign of Subjective Cognitive Decline |
title_full_unstemmed |
White Matter Microstructural Damage as an Early Sign of Subjective Cognitive Decline |
title_sort |
white matter microstructural damage as an early sign of subjective cognitive decline |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2020-01-01 |
description |
Background and Objective: Subjective cognitive decline (SCD) is considered a preclinical state of Alzheimer’s disease (AD) and may represent a more advanced preclinical status than amnestic mild cognitive impairment (aMCI). Our aim was to explore changes in the white matter (WM) microstructure and their correlation with cognitive function in these AD-spectrum patients.Methods: Diffusion tensor images from 43 individuals with normal cognition (NC), 38 SCD patients, and 36 aMCI patients were compared using an atlas-based segmentation strategy. The correlation between diffusion parameters and cognitive function was further analyzed.Results: The anatomical pattern of WM impairment was generally similar between SCD and aMCI patients. However, aMCI patients showed significantly lower fractional anisotropy (i.e., corpus callosum forceps major and forceps minor) and increased mean diffusivity [i.e., bilateral anterior thalamic radiation (ATR), left corticospinal tract (CST), forceps minor, left cingulum (cingulate gyrus), left cingulum hippocampus, and left inferior fronto-occipital fasciculus (IFO)] in some tracts than did SCD subjects, indicating a disruption in WM microstructural integrity in the aMCI. Individuals with microstructural disruption in forceps minor, left cingulum (cingulate gyrus), and left cingulum hippocampus tracts performed worse in general cognition and memory function tests, as indicated by line regression analysis.Conclusion: SCD individuals had extensive WM microstructural damage in a pattern similar to that seen in aMCI, although presenting a cognitive performance comparable with that of cognitively healthy individuals. Our results suggest that WM integrity might precede objectively measurable memory decline and may be a potential early biomarker for AD. |
topic |
Alzheimer’s disease subjective cognitive decline amnestic mild cognitive impairment diffusion tensor imaging white matter pathway |
url |
https://www.frontiersin.org/article/10.3389/fnagi.2019.00378/full |
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doaj-f4242fd10ec4498bae5733df30c9c8012020-11-25T02:42:10ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652020-01-011110.3389/fnagi.2019.00378489637White Matter Microstructural Damage as an Early Sign of Subjective Cognitive DeclineCaimei Luo0Caimei Luo1Caimei Luo2Caimei Luo3Mengchun Li4Mengchun Li5Mengchun Li6Mengchun Li7Ruomeng Qin8Ruomeng Qin9Ruomeng Qin10Ruomeng Qin11Haifeng Chen12Haifeng Chen13Haifeng Chen14Haifeng Chen15Dan Yang16Dan Yang17Dan Yang18Dan Yang19Lili Huang20Lili Huang21Lili Huang22Lili Huang23Renyuan Liu24Renyuan Liu25Renyuan Liu26Renyuan Liu27Yun Xu28Yun Xu29Yun Xu30Yun Xu31Feng Bai32Feng Bai33Feng Bai34Feng Bai35Hui Zhao36Hui Zhao37Hui Zhao38Hui Zhao39Department of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, ChinaJiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, ChinaJiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, ChinaNanjing Neuropsychiatry Clinic Medical Center, Nanjing, ChinaDepartment of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, ChinaJiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, ChinaJiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, ChinaNanjing Neuropsychiatry Clinic Medical Center, Nanjing, ChinaDepartment of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, ChinaJiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, ChinaJiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, ChinaNanjing Neuropsychiatry Clinic Medical Center, Nanjing, ChinaDepartment of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, ChinaJiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, ChinaJiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, ChinaNanjing Neuropsychiatry Clinic Medical Center, Nanjing, ChinaDepartment of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, ChinaJiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, ChinaJiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, ChinaNanjing Neuropsychiatry Clinic Medical Center, Nanjing, ChinaDepartment of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, ChinaJiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, ChinaJiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, ChinaNanjing Neuropsychiatry Clinic Medical Center, Nanjing, ChinaDepartment of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, ChinaJiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, ChinaJiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, ChinaNanjing Neuropsychiatry Clinic Medical Center, Nanjing, ChinaDepartment of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, ChinaJiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, ChinaJiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, ChinaNanjing Neuropsychiatry Clinic Medical Center, Nanjing, ChinaDepartment of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, ChinaJiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, ChinaJiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, ChinaNanjing Neuropsychiatry Clinic Medical Center, Nanjing, ChinaDepartment of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, ChinaJiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, ChinaJiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, ChinaNanjing Neuropsychiatry Clinic Medical Center, Nanjing, ChinaBackground and Objective: Subjective cognitive decline (SCD) is considered a preclinical state of Alzheimer’s disease (AD) and may represent a more advanced preclinical status than amnestic mild cognitive impairment (aMCI). Our aim was to explore changes in the white matter (WM) microstructure and their correlation with cognitive function in these AD-spectrum patients.Methods: Diffusion tensor images from 43 individuals with normal cognition (NC), 38 SCD patients, and 36 aMCI patients were compared using an atlas-based segmentation strategy. The correlation between diffusion parameters and cognitive function was further analyzed.Results: The anatomical pattern of WM impairment was generally similar between SCD and aMCI patients. However, aMCI patients showed significantly lower fractional anisotropy (i.e., corpus callosum forceps major and forceps minor) and increased mean diffusivity [i.e., bilateral anterior thalamic radiation (ATR), left corticospinal tract (CST), forceps minor, left cingulum (cingulate gyrus), left cingulum hippocampus, and left inferior fronto-occipital fasciculus (IFO)] in some tracts than did SCD subjects, indicating a disruption in WM microstructural integrity in the aMCI. Individuals with microstructural disruption in forceps minor, left cingulum (cingulate gyrus), and left cingulum hippocampus tracts performed worse in general cognition and memory function tests, as indicated by line regression analysis.Conclusion: SCD individuals had extensive WM microstructural damage in a pattern similar to that seen in aMCI, although presenting a cognitive performance comparable with that of cognitively healthy individuals. Our results suggest that WM integrity might precede objectively measurable memory decline and may be a potential early biomarker for AD.https://www.frontiersin.org/article/10.3389/fnagi.2019.00378/fullAlzheimer’s diseasesubjective cognitive declineamnestic mild cognitive impairmentdiffusion tensor imagingwhite matter pathway |