Impact of photoreceptor density in a 3D simulation of panretinal laser photocoagulation
Abstract Background During panretinal photocoagulation (PRP), the outer retina, especially the photoreceptors, are destroyed. During such procedures, the impact of the retinal photocoagulation, which is performed in the same photocoagulated area, may change if it is applied to different locations wi...
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doaj-f42a7917336944d787899f63aa4bd05a2021-05-09T11:21:51ZengBMCBMC Ophthalmology1471-24152021-05-012111810.1186/s12886-021-01945-zImpact of photoreceptor density in a 3D simulation of panretinal laser photocoagulationKentaro Nishida0Shizuka Takahashi1Hirokazu Sakaguchi2Shigeru Sato3Masanori Kanai4Akihiko Shiraki5Taku Wakabayashi6Chikako Hara7Yoko Fukushima8Susumu Sakimoto9Kaori Sayanagi10Ryo Kawasaki11Kohji Nishida12Department of Ophthalmology, Osaka University Graduate School of MedicineDepartment of Ophthalmology, Osaka University Graduate School of MedicineDepartment of Ophthalmology, Osaka University Graduate School of MedicineDepartment of Ophthalmology, Osaka University Graduate School of MedicineDepartment of Ophthalmology, Osaka University Graduate School of MedicineDepartment of Ophthalmology, Osaka University Graduate School of MedicineDepartment of Ophthalmology, Osaka University Graduate School of MedicineDepartment of Ophthalmology, Osaka University Graduate School of MedicineDepartment of Ophthalmology, Osaka University Graduate School of MedicineDepartment of Ophthalmology, Osaka University Graduate School of MedicineDepartment of Ophthalmology, Osaka University Graduate School of MedicineDepartment of Ophthalmology, Osaka University Graduate School of MedicineDepartment of Ophthalmology, Osaka University Graduate School of MedicineAbstract Background During panretinal photocoagulation (PRP), the outer retina, especially the photoreceptors, are destroyed. During such procedures, the impact of the retinal photocoagulation, which is performed in the same photocoagulated area, may change if it is applied to different locations with different photoreceptor densities. Thus, we aimed to evaluate the influence of photoreceptor density on PRP. Methods We constructed a three-dimensional (3D) average distribution of photoreceptors with 3D computer-aided design (CAD) software using previously derived photoreceptor density data and calculated the number of photoreceptors destroyed by scatter PRP and full-scatter PRP (size 400-μm on the retina, spacing 1.0 spot) using a geometry-based simulation. To investigate the impact of photoreceptor density on PRP, we calculated the ratio of the number of photoreceptors destroyed to the total number of photoreceptors, termed the photoreceptor destruction index. Results In this 3D simulation, the total number of photoreceptors was 96,571,900. The total number of photoreceptors destroyed by scatter PRP and full-scatter PRP were 15,608,200 and 19,120,600, respectively, and the respective photoreceptor destruction indexes were 16.2 and 19.8%, respectively. Conclusions Scatter PRP is expected to have 4/5 of the number of photoreceptors destroyed by full-scatter PRP.https://doi.org/10.1186/s12886-021-01945-zComputer based methodsPanretinal laser photocoagulationPhotocoagulation indexPhotoreceptor densityPhotoreceptor destruction index |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kentaro Nishida Shizuka Takahashi Hirokazu Sakaguchi Shigeru Sato Masanori Kanai Akihiko Shiraki Taku Wakabayashi Chikako Hara Yoko Fukushima Susumu Sakimoto Kaori Sayanagi Ryo Kawasaki Kohji Nishida |
spellingShingle |
Kentaro Nishida Shizuka Takahashi Hirokazu Sakaguchi Shigeru Sato Masanori Kanai Akihiko Shiraki Taku Wakabayashi Chikako Hara Yoko Fukushima Susumu Sakimoto Kaori Sayanagi Ryo Kawasaki Kohji Nishida Impact of photoreceptor density in a 3D simulation of panretinal laser photocoagulation BMC Ophthalmology Computer based methods Panretinal laser photocoagulation Photocoagulation index Photoreceptor density Photoreceptor destruction index |
author_facet |
Kentaro Nishida Shizuka Takahashi Hirokazu Sakaguchi Shigeru Sato Masanori Kanai Akihiko Shiraki Taku Wakabayashi Chikako Hara Yoko Fukushima Susumu Sakimoto Kaori Sayanagi Ryo Kawasaki Kohji Nishida |
author_sort |
Kentaro Nishida |
title |
Impact of photoreceptor density in a 3D simulation of panretinal laser photocoagulation |
title_short |
Impact of photoreceptor density in a 3D simulation of panretinal laser photocoagulation |
title_full |
Impact of photoreceptor density in a 3D simulation of panretinal laser photocoagulation |
title_fullStr |
Impact of photoreceptor density in a 3D simulation of panretinal laser photocoagulation |
title_full_unstemmed |
Impact of photoreceptor density in a 3D simulation of panretinal laser photocoagulation |
title_sort |
impact of photoreceptor density in a 3d simulation of panretinal laser photocoagulation |
publisher |
BMC |
series |
BMC Ophthalmology |
issn |
1471-2415 |
publishDate |
2021-05-01 |
description |
Abstract Background During panretinal photocoagulation (PRP), the outer retina, especially the photoreceptors, are destroyed. During such procedures, the impact of the retinal photocoagulation, which is performed in the same photocoagulated area, may change if it is applied to different locations with different photoreceptor densities. Thus, we aimed to evaluate the influence of photoreceptor density on PRP. Methods We constructed a three-dimensional (3D) average distribution of photoreceptors with 3D computer-aided design (CAD) software using previously derived photoreceptor density data and calculated the number of photoreceptors destroyed by scatter PRP and full-scatter PRP (size 400-μm on the retina, spacing 1.0 spot) using a geometry-based simulation. To investigate the impact of photoreceptor density on PRP, we calculated the ratio of the number of photoreceptors destroyed to the total number of photoreceptors, termed the photoreceptor destruction index. Results In this 3D simulation, the total number of photoreceptors was 96,571,900. The total number of photoreceptors destroyed by scatter PRP and full-scatter PRP were 15,608,200 and 19,120,600, respectively, and the respective photoreceptor destruction indexes were 16.2 and 19.8%, respectively. Conclusions Scatter PRP is expected to have 4/5 of the number of photoreceptors destroyed by full-scatter PRP. |
topic |
Computer based methods Panretinal laser photocoagulation Photocoagulation index Photoreceptor density Photoreceptor destruction index |
url |
https://doi.org/10.1186/s12886-021-01945-z |
work_keys_str_mv |
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