Conformational changes of apoB-100 in SMase-modified LDL mediate formation of large aggregates at acidic pH[S]

Conformational changes of apoB-100 in SMase-modified LDL mediate formation of large aggregates at acidic pH[S]

During atherogenesis, the extracellular pH of atherosclerotic lesions decreases. Here, we examined the effect of low, but physiologically plausible pH on aggregation of modified LDL, one of the key processes in atherogenesis. LDL was treated with SMase, and aggregation of the SMase-treated LDL was f...

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Bibliographic Details
Main Authors: Mia Sneck, Su Duy Nguyen, Tero Pihlajamaa, Gebrenegus Yohannes, Marja-Liisa Riekkola, Ross Milne, Petri T. Kovanen, Katariina Öörni
Format: Article
Language:English
Published: Elsevier 2012-09-01
Series:Journal of Lipid Research
Subjects:
sphingomyelinase
aggregation
atherosclerosis
apolipoprotein
low density lipoprotein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520418279

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http://www.sciencedirect.com/science/article/pii/S0022227520418279

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