Monitoring Methylmalonic Aciduria by NMR Urinomics

The paper reports on monitoring methylmalonic aciduria (MMA)-specific and non-specific metabolites via NMR urinomics. Five patients have been monitored over periods of time; things involved were diet, medication and occasional episodes of failing to comply with prescribed diets. An extended dataset...

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Main Authors:	Alina Nicolescu, Daniela Blanita, Chiril Boiciuc, Victoria Hlistun, Mihaela Cristea, Dorina Rotaru, Ludmila Pinzari, Ana Oglinda, Adela Stamati, Isabela Tarcomnicu, Andreea Tutulan-Cunita, Danae Stambouli, Sergiu Gladun, Ninel Revenco, Natalia Uşurelu, Calin Deleanu
Format:	Article
Language:	English
Published:	MDPI AG 2020-11-01
Series:	Molecules
Subjects:	methylmalonic aciduria methylmalonic acid NMR spectroscopy urine metabolomics
Online Access:	https://www.mdpi.com/1420-3049/25/22/5312

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spelling	doaj-f4338ef928ce4caa9adff5cefe9c60ad2020-11-25T03:59:37ZengMDPI AGMolecules1420-30492020-11-01255312531210.3390/molecules25225312Monitoring Methylmalonic Aciduria by NMR UrinomicsAlina Nicolescu0Daniela Blanita1Chiril Boiciuc2Victoria Hlistun3Mihaela Cristea4Dorina Rotaru5Ludmila Pinzari6Ana Oglinda7Adela Stamati8Isabela Tarcomnicu9Andreea Tutulan-Cunita10Danae Stambouli11Sergiu Gladun12Ninel Revenco13Natalia Uşurelu14Calin Deleanu15“Petru Poni” Institute of Macromolecular Chemistry, Romanian Academy, Aleea Grigore Ghica Voda 41A, RO-700487 Iasi, RomaniaInstitute of Mother and Child, Str. Burebista 93, MD-2062 Chisinau, MoldovaInstitute of Mother and Child, Str. Burebista 93, MD-2062 Chisinau, MoldovaInstitute of Mother and Child, Str. Burebista 93, MD-2062 Chisinau, Moldova“Petru Poni” Institute of Macromolecular Chemistry, Romanian Academy, Aleea Grigore Ghica Voda 41A, RO-700487 Iasi, Romania“Gheorghe Palade” City Clinical Hospital, Str. Melestiu 20, MD-2001 Chisinau, MoldovaInstitute of Mother and Child, Str. Burebista 93, MD-2062 Chisinau, Moldova“Nicolae Testemitanu” State University of Medicine and Pharmacy, Bd. Stefan cel Mare si Sfint 165, MD-2004 Chisinau, Moldova“Nicolae Testemitanu” State University of Medicine and Pharmacy, Bd. Stefan cel Mare si Sfint 165, MD-2004 Chisinau, MoldovaCytogenomic Medical Laboratory, Calea Floreasca 35, RO-014453 Bucharest, RomaniaCytogenomic Medical Laboratory, Calea Floreasca 35, RO-014453 Bucharest, RomaniaCytogenomic Medical Laboratory, Calea Floreasca 35, RO-014453 Bucharest, RomaniaInstitute of Mother and Child, Str. Burebista 93, MD-2062 Chisinau, Moldova“Nicolae Testemitanu” State University of Medicine and Pharmacy, Bd. Stefan cel Mare si Sfint 165, MD-2004 Chisinau, MoldovaInstitute of Mother and Child, Str. Burebista 93, MD-2062 Chisinau, Moldova“Petru Poni” Institute of Macromolecular Chemistry, Romanian Academy, Aleea Grigore Ghica Voda 41A, RO-700487 Iasi, RomaniaThe paper reports on monitoring methylmalonic aciduria (MMA)-specific and non-specific metabolites via NMR urinomics. Five patients have been monitored over periods of time; things involved were diet, medication and occasional episodes of failing to comply with prescribed diets. An extended dataset of targeted metabolites is presented, and correlations with the type of MMA are underlined. A survey of previous NMR studies on MMA is also presented.https://www.mdpi.com/1420-3049/25/22/5312methylmalonic aciduriamethylmalonic acidNMR spectroscopyurinemetabolomics
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Alina Nicolescu Daniela Blanita Chiril Boiciuc Victoria Hlistun Mihaela Cristea Dorina Rotaru Ludmila Pinzari Ana Oglinda Adela Stamati Isabela Tarcomnicu Andreea Tutulan-Cunita Danae Stambouli Sergiu Gladun Ninel Revenco Natalia Uşurelu Calin Deleanu
spellingShingle	Alina Nicolescu Daniela Blanita Chiril Boiciuc Victoria Hlistun Mihaela Cristea Dorina Rotaru Ludmila Pinzari Ana Oglinda Adela Stamati Isabela Tarcomnicu Andreea Tutulan-Cunita Danae Stambouli Sergiu Gladun Ninel Revenco Natalia Uşurelu Calin Deleanu Monitoring Methylmalonic Aciduria by NMR Urinomics Molecules methylmalonic aciduria methylmalonic acid NMR spectroscopy urine metabolomics
author_facet	Alina Nicolescu Daniela Blanita Chiril Boiciuc Victoria Hlistun Mihaela Cristea Dorina Rotaru Ludmila Pinzari Ana Oglinda Adela Stamati Isabela Tarcomnicu Andreea Tutulan-Cunita Danae Stambouli Sergiu Gladun Ninel Revenco Natalia Uşurelu Calin Deleanu
author_sort	Alina Nicolescu
title	Monitoring Methylmalonic Aciduria by NMR Urinomics
title_short	Monitoring Methylmalonic Aciduria by NMR Urinomics
title_full	Monitoring Methylmalonic Aciduria by NMR Urinomics
title_fullStr	Monitoring Methylmalonic Aciduria by NMR Urinomics
title_full_unstemmed	Monitoring Methylmalonic Aciduria by NMR Urinomics
title_sort	monitoring methylmalonic aciduria by nmr urinomics
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2020-11-01
description	The paper reports on monitoring methylmalonic aciduria (MMA)-specific and non-specific metabolites via NMR urinomics. Five patients have been monitored over periods of time; things involved were diet, medication and occasional episodes of failing to comply with prescribed diets. An extended dataset of targeted metabolites is presented, and correlations with the type of MMA are underlined. A survey of previous NMR studies on MMA is also presented.
topic	methylmalonic aciduria methylmalonic acid NMR spectroscopy urine metabolomics
url	https://www.mdpi.com/1420-3049/25/22/5312
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Monitoring Methylmalonic Aciduria by NMR Urinomics

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