New potential antitumoral agents of polyphenolic nature obtained from Helleborus purpurascens by membranary micro- and ultrafiltration techniques
The in vitro action of some total aqueous and hydroalcoholic extracts and of their concentrate or permeate fractions, separated by membranary micro- and ultrafiltrations of the primary homogenates, obtained from Helleborus purpurascens ethnomedicinal plant, upon the cell protein biosynthesis, prolif...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
"Alexandru Ioan Cuza" University of Iași
2010-06-01
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| Series: | Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara |
| Online Access: | http://www.gbm.bio.uaic.ro/index.php/gbm/article/view/886 |
| Summary: | The in vitro action of some total aqueous and hydroalcoholic extracts and of their concentrate or permeate
fractions, separated by membranary micro- and ultrafiltrations of the primary homogenates, obtained from Helleborus
purpurascens ethnomedicinal plant, upon the cell protein biosynthesis, proliferation, viability and development of the
HeLa cancerous cells cultures was investigated. The significant proteinsynthesis alteration, protein dynamics
modification, decrease of total cell number, cell viability diminution, inhibitory impact upon the cell cultures
development, during studied evolution period, suggest the behaviour of these polyphenolic hellebore extracts as in vitro
active cytostatic and cytotoxic agents. Our preliminary characterization of these vegetal biopreparations as protein,
mitotic, growth inhibitors offers the informational background for further investigations, on many other cancerous and
normal cell lines and adequate experimental models to in vitro prescreening, as well as for their introduction in the in vivo
antitumoral screening program on different experimental tumoral systems. |
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| ISSN: | 1582-3571 2248-3276 |