Robust phenotype prediction from gene expression data using differential shrinkage of co-regulated genes
Abstract Discovery of robust diagnostic or prognostic biomarkers is a key to optimizing therapeutic benefit for select patient cohorts - an idea commonly referred to as precision medicine. Most discovery studies to derive such markers from high-dimensional transcriptomics datasets are weakly powered...
Main Authors: | Kourosh Zarringhalam, David Degras, Christoph Brockel, Daniel Ziemek |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-01-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-018-19635-0 |
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